ZEARALANONE
- CAS No.
- 5975-78-0
- Chemical Name:
- ZEARALANONE
- Synonyms
- Zanone;P-1502;Ccris 9235;ZEARALANONE;(S)-Zearalanone;Zearalanone solution;Zearalanone Standard;Zearalanone in Methanol;(S)-Zearalanone, P 1502, Zanone;(S)-Zearalanone in Acetonitrile
- CBNumber:
- CB1769935
- Molecular Formula:
- C18H24O5
- Molecular Weight:
- 320.38
- MDL Number:
- MFCD00135821
- MOL File:
- 5975-78-0.mol
- MSDS File:
- SDS
| Melting point | 184-186°C |
|---|---|
| Boiling point | 576.8±50.0 °C(Predicted) |
| Density | 1.148±0.06 g/cm3(Predicted) |
| Flash point | 2℃ |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 7.83±0.40(Predicted) |
| color | White to Off-White |
| FDA UNII | 133DU2F2VS |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335-H351 | |||||||||
| Precautionary statements | P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn,F | |||||||||
| Risk Statements | 20/21/22-36/37/38-40-36-11 | |||||||||
| Safety Statements | 22-26-36-36/37-16 | |||||||||
| RIDADR | UN 1648 3 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29322090 | |||||||||
| NFPA 704 |
|
ZEARALANONE price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Z0167 | Zearalanone | 5975-78-0 | 1mg | $24.28 | 2024-03-01 | Buy |
| Sigma-Aldrich | 32193 | Zearalanone solution 10 μg/mL in acetonitrile, analytical standard | 5975-78-0 | 1.2ml | $750 | 2022-05-15 | Buy |
| Cayman Chemical | 19459 | Zearalanone ≥98% | 5975-78-0 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 19459 | Zearalanone ≥98% | 5975-78-0 | 5mg | $143 | 2024-03-01 | Buy |
| Sigma-Aldrich | Z0167 | Zearalanone | 5975-78-0 | 5mg | $210 | 2024-03-01 | Buy |
ZEARALANONE Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Uses
A secondary metabolite of Zearalenone (ZON). The macrocyclic lactone Zearalanone used in the synthesis of d,l-Zearalanol.
Uses
Zearalanone is a minor component of the zearalenone complex produced by several species of Fusarium. Like the more abundant analogues, zearalanone causes estrogenic effects in domestic livestock. Zearalanone is a metabolite of α-zearalanol, a commercially available growth promotant in animals, and is a useful standard for detection of zearanol-contaminated products and Fusarium-contaminated grains.
Definition
ChEBI: Zearalanone is a member of resorcinols and a macrolide.
General Description
Zearalanone (ZEA) or F-2 toxin, a nonsteroidal estrogenic mycotoxin is produced by various Fusarium species. Fusarium graminearum is considered as the primary producer of zearalanone. It is usually seen in moldy hay, high-moisture corn, corn infected before harvest etc.
Biological Activity
zearalanone (zan) is an estrogen receptor agonist and also an androgen receptor antagonist [1].zearalenone (zen), a β-resorcyclic acid lactone (ral), is a non-steroidal estrogenic mycotoxin biosynthesized by several fusarium species. zearalenone (zen) is the well-known mycotoxin present in numerous agricultural products [1][2][3][4]. in the human endometrial ishikawa cell line, zearalenone (zen) exhibited strong oestrogenicity [4].when incubated fusarium semitectum on sorghum, the ratio of zan to zen remained constant after 5 days, suggesting that zan might not be suitable for use as an internal standard [5].zearalanone, a major phase i metabolite of zearalenone (zen), is an estrogen receptor agonist and also an androgen receptor antagonist. in mcf-7 cells, zearalanone strongly induced cell proliferation with ec50 value of 1.21 nm and showed significant estrogenic activity. zearalanone behaved as full herα agonist. in palm cells, zearalanone acted as a har antagonist that strongly inhibited the luciferase activity induced by 0.3 nm of r1881, the synthetic androgen [1].
Biochem/physiol Actions
Zearalanone is believed to cause vulvovaginitis and estrogenic responses in swine.
References
[1]. molina-molina jm, real m, jimenez-diaz i, et al. assessment of estrogenic and anti-androgenic activities of the mycotoxin zearalenone and its metabolites using in vitro receptor-specific bioassays. food chem toxicol.2014 dec;74:233-9.
[2]. baldwin rs, williams rd, terry mk. zeranol: a review of the metabolism, toxicology, and analytical methods for detection of tissue residues. regul toxicol pharmacol. 1983 mar;3(1):9-25.
[3]. migdalof bh, dugger ha, heider jg, et al. biotransformation of zeranol: disposition and metabolism in the female rat, rabbit, dog, monkey and man. xenobiotica. 1983 apr;13(4):209-21.
[4]. le guevel r, pakdel f. assessment of oestrogenic potency of chemicals used as growth promoter by in-vitro methods. hum reprod. 2001 may;16(5):1030-6.
[5]. aoyama k, ishikuro e, noriduki h, et al. formation ratios of zearalanone, zearalenols, and zearalanols versus zearalenone during incubation of fusarium semitectum on sorghum and ratios in naturally contaminated sorghum. shokuhin eiseigaku zasshi. 2015;56(6):247-51.
ZEARALANONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 4084 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| Shanghai JONLN Reagent Co., Ltd. | 400-0066400 13621662912 | 422131432@qq.com | China | 9978 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |