5-Bromo-2-nitropyridine
- CAS No.
- 39856-50-3
- Chemical Name:
- 5-Bromo-2-nitropyridine
- Synonyms
- 2-NITRO-5-BROMOPYRIDINE;AKOS BBS-00001330;5-Bromo-2-nitropyrid;3-BROMO-6-NITROPYRIDINE;5-BROMO-2-NITROPYRIDINE;5-Bromo-2-notropyridine;2-Nitro-5-borMopyridine;Palbociclib impurity A;Pyridine, 5-broMo-2-nitro-;5-Bromo-2-nitropyridine 99%
- CBNumber:
- CB1773370
- Molecular Formula:
- C5H3BrN2O2
- Molecular Weight:
- 202.99
- MDL Number:
- MFCD00160411
- MOL File:
- 39856-50-3.mol
- MSDS File:
- SDS
Melting point | 148-150 °C (lit.) |
---|---|
Boiling point | 292.3±20.0 °C(Predicted) |
Density | 1.833±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
pka | -4.95±0.22(Predicted) |
color | White to yellow to beige powder or crystal or chunks |
BRN | 120878 |
InChI | InChI=1S/C5H3BrN2O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H |
InChIKey | ATXXLNCPVSUCNK-UHFFFAOYSA-N |
SMILES | C1([N+]([O-])=O)=NC=C(Br)C=C1 |
CAS DataBase Reference | 39856-50-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36/37 | |||||||||
WGK Germany | 3 | |||||||||
HazardClass | IRRITANT | |||||||||
PackingGroup | III | |||||||||
HS Code | 29339900 | |||||||||
NFPA 704 |
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5-Bromo-2-nitropyridine price More Price(33)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 520411 | 5-Bromo-2-nitropyridine 99% | 39856-50-3 | 5g | $23.76 | 2024-03-01 | Buy |
TCI Chemical | B2766 | 5-Bromo-2-nitropyridine >98.0%(GC) | 39856-50-3 | 1g | $20 | 2024-03-01 | Buy |
TCI Chemical | B2766 | 5-Bromo-2-nitropyridine >98.0%(GC) | 39856-50-3 | 5g | $57 | 2024-03-01 | Buy |
Alfa Aesar | L19748 | 5-Bromo-2-nitropyridine, 98+% | 39856-50-3 | 5g | $90.65 | 2024-03-01 | Buy |
Alfa Aesar | L19748 | 5-Bromo-2-nitropyridine, 98+% | 39856-50-3 | 1g | $30.6 | 2021-12-16 | Buy |
5-Bromo-2-nitropyridine Chemical Properties,Uses,Production
Chemical Properties
Colorless solid
Uses
5-Bromo-2-nitropyridine is employed as a reagent in the synthesis of novel benzinidazoles, potent inhibitors of TIE-2 and VEGFR-2 Tyrosine (T899975) kinase receptors.
Preparation
5-Bromo-2-nitropyridine was prepared from the corresponding amine via hydrogen peroxide oxidation in large scale production. N-Bromosuccinimide (NBS) bromination of 2-aminopyridine in acetonitrile at 0-5 °C delivered 5-bromo-2- aminopyridine with good regioselectivity (>20:1). The brominated amino-pyridine was then reacted with the oxidant mixture, yielding 5-Bromo-2-nitropyridine after dilution with water and isopropanol[1].
Synthesis Reference(s)
[1] Agosti, Alessandro, et al. "Handling Hydrogen Peroxide Oxidations on a Large Scale: Synthesis of 5-Bromo-2-nitropyridine." Organic Process Research & Development 21.3(2017):451-459.
5-Bromo-2-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Changzhou Fullone Chemical Co., Ltd. | +86-13328197671 +86-13861172460 | sales@borenchem.cn | China | 1055 | 58 |
Wuhan BJM Pharm Inc | +86-027-5234-1919 +8613545198479 | sales03@benjaminpharmchem.com | China | 689 | 58 |
Terma Medicare India Pvt.,Ltd | +8613916485955 | shivshanghai@yahoo.com | India | 150 | 58 |
Hong Kong Excellence Biotechnology Co., Ltd. | ada@sh-teruiop.com | China | 875 | 58 | |
Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 286 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20287 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 970 | 58 |
Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 | niki@zlchemi.com | China | 724 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
View Lastest Price from 5-Bromo-2-nitropyridine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-11-22 | 5-Bromo-2-nitropyridine
39856-50-3
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-11-22 | 5-Bromo-2-nitropyridine
39856-50-3
|
US $30.00 / kg | 1kg | 99% | 2000kg | hebei hongtan Biotechnology Co., Ltd | ||
2024-11-21 | 5-Bromo-2-nitropyridine
39856-50-3
|
US $10.00 / kg | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd |
- 5-Bromo-2-nitropyridine
39856-50-3
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
- 5-Bromo-2-nitropyridine
39856-50-3
- US $30.00 / kg
- 99%
- hebei hongtan Biotechnology Co., Ltd
- 5-Bromo-2-nitropyridine
39856-50-3
- US $10.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
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