- 5-Bromo-2-nitropyridine
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- $0.00 / 1KG
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2024-09-06
- CAS:39856-50-3
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 30tons/month
- 5-Bromo-2-nitropyridine
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- $100.00 / 1kg
-
2024-09-06
- CAS:39856-50-3
- Min. Order: 1kg
- Purity: 99.9%
- Supply Ability: 20tons
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| 5-Bromo-2-nitropyridine Basic information |
| 5-Bromo-2-nitropyridine Chemical Properties |
Melting point | 148-150 °C (lit.) | Boiling point | 292.3±20.0 °C(Predicted) | density | 1.833±0.06 g/cm3(Predicted) | storage temp. | Inert atmosphere,Room Temperature | solubility | Chloroform (Slightly), Methanol (Slightly) | form | Solid | pka | -4.95±0.22(Predicted) | color | White to yellow to beige powder or crystal or chunks | BRN | 120878 | InChI | InChI=1S/C5H3BrN2O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H | InChIKey | ATXXLNCPVSUCNK-UHFFFAOYSA-N | SMILES | C1([N+]([O-])=O)=NC=C(Br)C=C1 | CAS DataBase Reference | 39856-50-3(CAS DataBase Reference) |
Hazard Codes | Xi | Risk Statements | 36/37/38 | Safety Statements | 26-36/37 | WGK Germany | 3 | HazardClass | IRRITANT | PackingGroup | III | HS Code | 29339900 |
| 5-Bromo-2-nitropyridine Usage And Synthesis |
Chemical Properties | Colorless solid | Uses | 5-Bromo-2-nitropyridine is employed as a reagent in the synthesis of novel benzinidazoles, potent inhibitors of TIE-2 and VEGFR-2 Tyrosine (T899975) kinase receptors. | Preparation | 5-Bromo-2-nitropyridine was prepared from the corresponding amine via hydrogen peroxide oxidation in large scale production. N-Bromosuccinimide (NBS) bromination of 2-aminopyridine in acetonitrile at 0-5 °C delivered 5-bromo-2- aminopyridine with good regioselectivity (>20:1). The brominated amino-pyridine was then reacted with the oxidant mixture, yielding 5-Bromo-2-nitropyridine after dilution with water and isopropanol[1].
![5-Bromo-2-nitropyridine 5-Bromo-2-nitropyridine](/NewsImg/2023-11-09/6383513262877682678992569.jpg) | Synthesis Reference(s) | [1] Agosti, Alessandro, et al. "Handling Hydrogen Peroxide Oxidations on a Large Scale: Synthesis of 5-Bromo-2-nitropyridine." Organic Process Research & Development 21.3(2017):451-459. |
| 5-Bromo-2-nitropyridine Preparation Products And Raw materials |
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