ChemicalBook >> CAS DataBase List >>3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]-

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]-

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]- structure

CAS No.: 1458674-25-3

Chemical Name:: 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]-

Synonyms: IMP-1700;1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]-3-quinolinecarboxylic acid;3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]-

CBNumber:: CB18341063

Molecular Formula:: C25H22F4N4O3S

Molecular Weight:: 534.53

MDL Number:

MOL File:: 1458674-25-3.mol

Last updated:2023-05-18 11:31:14

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3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]- Properties

Boiling point	677.3±65.0 °C(Predicted)
Density	1.564±0.06 g/cm3(Predicted)
storage temp.	-20°
solubility	Soluble in DMSO (up to 25 mg/ml).
pka	6.44±0.41(Predicted)
form	solid
color	White
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]- Chemical Properties,Uses,Production

Description

IMP-1700 (1458674-25-3) is a potent inhibitor of the bacterial DNA double-strand break repair complex AddAB. It is capable of synergistic sensitization of methicillin-resistant staphylococcus aureus (MRSA) to ciprofloxacin (EC50?= 0.6nM).? IMP-1700 is an important new tool for exploring new treatment options for drug resistant bacteria.

Uses

IMP-1700 is an important tool for exploring new treatment options for drug resistant bacteria. A potent inhibitor of the bacterial DNA double-strand break repair complex AddAB.

References

1) Lim?et al.?(2019),?Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus; Bioorg. Med. Chem.,?27?114962

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]- Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ChemeGen 中国	18818260767	sales@chemegen.com	China	6975	58
Beijing Biocreative Technology Co., Ltd.	15522676233	3007606172@qq.com	China	1249	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	5587	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8739	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28091	58

Supplier	Advantage
ChemeGen 中国	58
Beijing Biocreative Technology Co., Ltd.	58
Nanjing Tengyi Biotechnology Co., Ltd	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58

1458674-25-3(3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]-)Related Search:

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3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]- IMP-1700 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]-3-quinolinecarboxylic acid 1458674-25-3 C25H22F4N4O3S