PJ-34
- CAS No.
- 344458-15-7
- Chemical Name:
- PJ-34
- Synonyms
- PI34;CS-723;PJ34 HC;PJ34(HCL);PJ 34;PJ-34;PJ34 hydrochL;PJ-34 USP/EP/BP;PJ 34 Hydrochloride;PARP Inhibitor VIII, PJ34;PJ34 hydrochloride, >=98%
- CBNumber:
- CB8972789
- Molecular Formula:
- C17H17N3O2HCl
- Molecular Weight:
- 0
- MDL Number:
- MFCD28142667
- MOL File:
- 344458-15-7.mol
- MSDS File:
- SDS
storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
---|---|
solubility | H2O: soluble22mg/mL |
form | White solid |
color | white to yellow |
Sensitive | Light Sensitive & Hygroscopic |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
FDA UNII | VHK9YBZ6SB |
SAFETY
Risk and Safety Statements
Safety Statements | 22-24/25 |
---|---|
WGK Germany | 3 |
HS Code | 29339900 |
PJ-34 price More Price(45)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 528150 | PARP Inhibitor VIII, PJ34 | 344458-15-7 | 1mg | $113 | 2024-03-01 | Buy |
Sigma-Aldrich | 528150 | PARP Inhibitor VIII, PJ34 | 344458-15-7 | 5mg | $303 | 2024-03-01 | Buy |
Alfa Aesar | J64413 | PARP Inhibitor VIII, PJ34 | 344458-15-7 | 5mg | $186 | 2023-06-20 | Buy |
Alfa Aesar | J64413 | PARP Inhibitor VIII, PJ34 | 344458-15-7 | 25mg | $692 | 2023-06-20 | Buy |
Cayman Chemical | 14440 | PJ-34 (hydrochloride) ≥98% | 344458-15-7 | 1mg | $37 | 2024-03-01 | Buy |
PJ-34 Chemical Properties,Uses,Production
Description
PJ-34 HCl (344458-15-7) is a potent and selective inhibitor of PARP1 and 2. EC50 = 20 nM.1?Reduces ischemia reperfusion injury in a mouse model.2 Displays anti-inflammatory effects in a transient focal cerebral ischemia mouse model.3 PJ-34 HCl causes PARP1 independent, p21 dependent mitotic arrest.4
Uses
A poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity. PJ-34 has a lethal effect on breast cancer cells, both in vitro and in vivo, in particular on breast cancer MCF-7.
Uses
PJ-34 hydrochloride hydrate has been used:
- as a poly(ADP-ribose) polymerase (PARP) inhibitor 1 in rats to test the effect of PAPR1 in neuropathic pain
- as a component of protein extraction buffer to enable visualization of the high-molecular-weight smear of PARylated proteins in various cell samples
- as PARP inhibitor in murine MLE-12 epithelial cell line
Definition
ChEBI: PJ34 hydrochloride is a hydrochloride salt prepared from equimolar amounts of PJ34 and hydrochloric acid. It has a role as an angiogenesis inhibitor, an anti-inflammatory agent, an antiatherosclerotic agent, an antineoplastic agent, an apoptosis inducer, a cardioprotective agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and a neuroprotective agent. It contains a PJ34(1+).
General Description
A cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 μM). Does not act as an antioxidant at higher concentrations (1 μM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H2O(Cat. No. 528151).
Biological Activity
Potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC 50 = 20 nM). ~ 1000-fold more potent than 3-Aminobenzamide . Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo .
Biochem/physiol Actions
Cell permeable: yes
storage
+4°C
References
1) Pellicciari et al. (2008), On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives; Chem. Med. Chem., 3 914 2) Crawford et al. (2010), Postischemic poly (ADP-ribose) polymerase (PARP) inhibition reduces ischemia reperfusion injury in a hind-limb ischemia model; Surgery, 148 110 3) Haddad et al. (2006), Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice; Br. J. Pharmacol., 149 23 4) Madison et al. (2011), The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest; DNA Repair, 10 1003
PJ-34 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9337 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 25022 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9624 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
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