- PJ34 hydrochloride
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- $48.00 / 10mg
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2024-11-19
- CAS:344458-15-7
- Min. Order:
- Purity: ≥95%
- Supply Ability: 10g
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| Product Name: | PJ-34 | | Synonyms: | PJ 34 Hydrochloride;N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamidehydrochloride;PARP Inhibitor VIII, PJ34;PJ-34 hydrate hydrochloride;AcetaMide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(diMethylaMino)-, hydrochloride;N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-(diMethylaMino)acetaMide;N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride;N,N-diMethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetaMide hydrochloride | | CAS: | 344458-15-7 | | MF: | C17H17N3O2HCl | | MW: | 0 | | EINECS: | | | Product Categories: | Amines;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 344458-15-7.mol |  |
| | PJ-34 Chemical Properties |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | H2O: soluble22mg/mL | | form | White solid | | color | white to yellow | | Water Solubility | water: 5mg/mL | | Sensitive | Light Sensitive & Hygroscopic | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 29339900 |
| | PJ-34 Usage And Synthesis |
| Description | PJ-34 HCl (344458-15-7) is a potent and selective inhibitor of PARP1 and 2. EC50 = 20 nM.1?Reduces ischemia reperfusion injury in a mouse model.2 Displays anti-inflammatory effects in a transient focal cerebral ischemia mouse model.3 PJ-34 HCl causes PARP1 independent, p21 dependent mitotic arrest.4 | | Uses | A poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity. PJ-34 has a lethal effect on breast cancer cells, both in vitro and in vivo, in particular on breast cancer MCF-7. | | Uses | PJ-34 hydrochloride hydrate has been used:
- as a poly(ADP-ribose) polymerase (PARP) inhibitor 1 in rats to test the effect of PAPR1 in neuropathic pain
- as a component of protein extraction buffer to enable visualization of the high-molecular-weight smear of PARylated proteins in various cell samples
- as PARP inhibitor in murine MLE-12 epithelial cell line
| | Definition | ChEBI: PJ34 hydrochloride is a hydrochloride salt prepared from equimolar amounts of PJ34 and hydrochloric acid. It has a role as an angiogenesis inhibitor, an anti-inflammatory agent, an antiatherosclerotic agent, an antineoplastic agent, an apoptosis inducer, a cardioprotective agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and a neuroprotective agent. It contains a PJ34(1+). | | General Description | A cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 μM). Does not act as an antioxidant at higher concentrations (1 μM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H2O(Cat. No. 528151). | | Biological Activity | Potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC 50 = 20 nM). ~ 1000-fold more potent than 3-Aminobenzamide . Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo . | | Biochem/physiol Actions | Cell permeable: yes | | storage | +4°C | | References | 1) Pellicciari et al. (2008), On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives; Chem. Med. Chem., 3 914
2) Crawford et al. (2010), Postischemic poly (ADP-ribose) polymerase (PARP) inhibition reduces ischemia reperfusion injury in a hind-limb ischemia model; Surgery, 148 110
3) Haddad et al. (2006), Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice; Br. J. Pharmacol., 149 23
4) Madison et al. (2011), The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest; DNA Repair, 10 1003 |
| | PJ-34 Preparation Products And Raw materials |
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