ChemicalBook >> CAS DataBase List >>3-Pyridinecarboxamide, 5-[2-[4-[2-(1H-indol-3-yl)ethyl]-1-piperazinyl]phenyl]-N-[3-(1-pyrrolidinyl)propyl]-
3-Pyridinecarboxamide, 5-[2-[4-[2-(1H-indol-3-yl)ethyl]-1-piperazinyl]phenyl]-N-[3-(1-pyrrolidinyl)propyl]-
![3-Pyridinecarboxamide, 5-[2-[4-[2-(1H-indol-3-yl)ethyl]-1-piperazinyl]phenyl]-N-[3-(1-pyrrolidinyl)propyl]- Structure](CAS/20210305/GIF/2043321-54-4.gif)
- CAS No.
- 2043321-54-4
- Chemical Name:
- 3-Pyridinecarboxamide, 5-[2-[4-[2-(1H-indol-3-yl)ethyl]-1-piperazinyl]phenyl]-N-[3-(1-pyrrolidinyl)propyl]-
- Synonyms
- AZ506;3-Pyridinecarboxamide, 5-[2-[4-[2-(1H-indol-3-yl)ethyl]-1-piperazinyl]phenyl]-N-[3-(1-pyrrolidinyl)propyl]-
- CBNumber:
- CB18864449
- Molecular Formula:
- C33H40N6O
- Molecular Weight:
- 536.71
- MDL Number:
- MOL File:
- 2043321-54-4.mol
Last updated:2024-07-02 08:55:01
3-Pyridinecarboxamide, 5-[2-[4-[2-(1H-indol-3-yl)ethyl]-1-piperazinyl]phenyl]-N-[3-(1-pyrrolidinyl)propyl]- Properties
| Boiling point | 774.2±60.0 °C(Predicted) |
|---|---|
| Density | 1.189±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 50 mg/mL (93.16 mM; Need ultrasonic) |
| pka | 13.22±0.46(Predicted) |
| form | Solid |
| color | Light yellow to light brown |
3-Pyridinecarboxamide, 5-[2-[4-[2-(1H-indol-3-yl)ethyl]-1-piperazinyl]phenyl]-N-[3-(1-pyrrolidinyl)propyl]- Chemical Properties,Uses,Production
Biological Activity
AZ506 is a potent SMYD2 inhibitor with an IC50 of 17 nM. AZ506 inhibits SMYD2 methyltransferase activity in cells, leading to a decrease in the SMYD2-mediated methylation signal[1]. AZ506 inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with an EC50 of 1.2 μM. AZ506 inhibits SMYD2-mediated methylation (p53-me in U2OS cells) with an IC50 of 2.43 μM[1].
References
[1]. Cowen SD, et al. Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors. J Med Chem. 2016;59(24):11079-11097.
3-Pyridinecarboxamide, 5-[2-[4-[2-(1H-indol-3-yl)ethyl]-1-piperazinyl]phenyl]-N-[3-(1-pyrrolidinyl)propyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
3-Pyridinecarboxamide, 5-[2-[4-[2-(1H-indol-3-yl)ethyl]-1-piperazinyl]phenyl]-N-[3-(1-pyrrolidinyl)propyl]- Suppliers
Global( 5)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 742 | 55 |
| Dezhou LonWel Pharmaceutical Technology Co., Ltd. | 13761310616 | 39324283@qq.com | China | 2003 | 58 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 998 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11974 | 58 |
3-Pyridinecarboxamide, 5-[2-[4-[2-(1H-indol-3-yl)ethyl]-1-piperazinyl]phenyl]-N-[3-(1-pyrrolidinyl)propyl]-
AZ506
2043321-54-4