16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
- CAS No.
- 77017-20-0
- Chemical Name:
- 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
- Synonyms
- BNKY015-BD01;Desonide Impurity M1;Budesonide Impurity 33;Budesonide Impurity 12;Pregna-1,4,9(11)-triene-16,17-diol-3,20-dione 21-acetate;Pregna-1,4,9(11)-triene-16α,17α-diol-3,20-dione 21-acetate;16,17-Dihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate;21-(Acetyloxy)-16α,17-dihydroxypregna-1,4,9(11)-triene-3,20-dione;16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate;(16α)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione
- CBNumber:
- CB1894903
- Molecular Formula:
- C23H28O6
- Molecular Weight:
- 400.46482
- MDL Number:
- MFCD12031469
- MOL File:
- 77017-20-0.mol
- MSDS File:
- SDS
Melting point | 213-215 °C(Solv: acetone (67-64-1); ligroine (8032-32-4)) |
---|---|
Boiling point | 576.7±50.0 °C(Predicted) |
Density | 1.31±0.1 g/cm3(Predicted) |
solubility | soluble in Acetone, Dichloromethane |
pka | 11.92±0.70(Predicted) |
Water Solubility | 38.72mg/L at 25℃ |
LogP | 2.26 at 25℃ |
FDA UNII | FWD7KH5JFZ |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() ![]() GHS08,GHS07,GHS09 |
---|---|
Signal word | Warning |
Hazard statements | H335-H361-H315-H319-H411 |
Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Medical Isotopes, Inc. | 67632 | (16α)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione | 77017-20-0 | 10mg | $640 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | CHM0006413 | 16,17,21-TRIHYDROXYPREGNA-1,4,9(11),TRIENE-3,20-DIONE-21-ACETATE 95.00% | 77017-20-0 | 10MG | $739.2 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | CHM0006413 | 16,17,21-TRIHYDROXYPREGNA-1,4,9(11),TRIENE-3,20-DIONE-21-ACETATE 95.00% | 77017-20-0 | 100MG | $1871.1 | 2021-12-16 | Buy |
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Chemical Properties,Uses,Production
Uses
Intermediate in the preparation of antiinflammatory compounds.
Synthesis
2-((10S,13S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate (1 kg, 2.73 mol), acetone (50 L) and purified water (2.6 L) were added to the reaction vessel, and dissolved by stirring at room temperature; Formic acid (0.4 L, 10.60 mol) and potassium permanganate (1.2 kg, 7.59 mol) were added in that order, and the reaction was stirred at room temperature for 1 h. The reaction was quenched by the addition of saturated sodium hydrogen sulfite solution (10 L) and manganese dioxide, and some solid impurities were removed by suction filtration, and the filtrate was evaporated under reduced pressure to give a large white solid. The filter cake was washed with water to give 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate (1.01 kg, 92.2%).
![37413-91-5](/CAS/GIF/37413-91-5.gif)
![77017-20-0](/CAS/GIF/77017-20-0.gif)
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Preparation Products And Raw materials
Raw materials
Preparation Products
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BIONNA MEDICINE CO.,LTD | 01056380788-8515; +8618518759099 | 790226113@qq.com | China | 52 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Wuhan Cell Pharmaceutical Co., Ltd | +86-13129979210 +86-13129979210 | sales@cellwh.com | China | 376 | 58 |
Hefei TianRui Pharmaceutical Chemical Co., Ltd. | +86-0551-68665055 +86-+86-18616906106 | sales@trywchem.com | China | 129 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5225 | 58 |
Bono Kangyuan (Beijing) Pharmaceutical Technology Co., Ltd | 010-56380788-8515 16619769925 | wch013@bionna.cn | China | 53 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Chemsky(shanghai)International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4505 | 50 | |
Beijing Comparison Pharmaceutical Technology Co., Ltd | 010-010-52878169 15801002657 | sales@bjcomparison.com | China | 4877 | 58 |
77017-20-0(16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate)Related Search:
1of4