ChemicalBook >> CAS DataBase List >>Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)-

Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)-

Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)- structure

CAS No.: 941580-60-5

Chemical Name:: Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)-

Synonyms: NVS-PI3-4;NVS PI3 4,NVS-PI-3-4,NVSPI34;Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)-

CBNumber:: CB19042543

Molecular Formula:: C20H26N4O3S

Molecular Weight:: 402.51

MDL Number:: MFCD28974557

MOL File:: 941580-60-5.mol

Last updated:2024-07-02 08:55:01

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Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)- Properties

Density	1.211±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 250 mg/mL (621.10 mM; Need ultrasonic)
form	Solid
pka	6.48±0.70(Predicted)
color	Off-white to yellow

Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)- Chemical Properties,Uses,Production

Biological Activity

NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 can be used for the research of allergies, inflammatory and cancer diseases[1][2]. NVS-PI3-4 shows an exquisite cellular selectivity for PI3Kγ. NVS-PI3-4 reduces IgE/antigen-mediated phosphorylation of PKB/Akt in p110δDA. NVS-PI3-4 (5 μM; 30 minutes; BMMCs) is not accumulate in specifically in mast cells[2].

References

[1]. Bruce I, et al. Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. Bioorg Med Chem Lett. 2012;22(17):5445-5450. [2]. Collmann E, et al. Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells’ route to allergy. J Allergy Clin Immunol. 2013;132(4):959-968.

Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)- Suppliers

Global( 4)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223;	psaitong@jm-bio.com	China	29778	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Suzhou Zhixin Biotechnology Co., Ltd.	0512-65118909 15162312715	sales@szzxbio.com	China	2992	58

Supplier	Advantage
Aladdin Scientific	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Suzhou Zhixin Biotechnology Co., Ltd.	58

Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)- NVS-PI3-4 NVS PI3 4,NVS-PI-3-4,NVSPI34 941580-60-5