ChemicalBook >> CAS DataBase List >>Lometrexol hydrate
Lometrexol hydrate
- CAS No.
- 1435784-14-7
- Chemical Name:
- Lometrexol hydrate
- Synonyms
- CBNumber:
- CB19272904
- Molecular Formula:
- C21H27N5O7
- Molecular Weight:
- 461.48
- MDL Number:
- MFCD21608516
- MOL File:
- 1435784-14-7.mol
Last updated:2024-07-02 08:55:01
Lometrexol hydrate Chemical Properties,Uses,Production
Biological Activity
Lometrexol hydrate (DDATHF hydrate), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity[1][2].
References
[1]. Xu L, et al. The effect of inhibiting glycinamide ribonucleotide formyl transferase on the development of neural tube in mice. Nutr Metab (Lond). 2016 Aug 23;13(1):56. [2]. Julie L Bronder, et al. Antifolates Targeting Purine Synthesis Allow Entry of Tumor Cells Into S Phase Regardless of p53 Function. Cancer Res. 2002 Sep 15;62(18):5236-41.
Lometrexol hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Lometrexol hydrate Suppliers
Global( 5)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5014 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9294 | 58 |
| Supplier | Advantage |
|---|---|
| Aladdin Scientific | 58 |
| TargetMol Chemicals Inc. | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 58 |
| RD International Technology Co., Limited | 58 |
1435784-14-7