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dichlorisone

CAS No.
7008-26-6
Chemical Name:
dichlorisone
Synonyms
Disoderm;Diloderm;9,11β-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione;(11β)-9,11-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione;Pregna-1,4-diene-3,20-dione, 9,11-dichloro-17,21-dihydroxy-, (11β)-;(8S,9R,10S,11S,13S,14S,17R)-9,11-dichloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CBNumber:
CB1932243
Molecular Formula:
C21H26Cl2O4
Molecular Weight:
413.34
MDL Number:
MFCD00232919
MOL File:
7008-26-6.mol
Last updated:2023-05-15 10:43:56

dichlorisone Properties

Melting point 238-241 °C (decomp)(Solv: acetone (67-64-1))
alpha D20 +134° (pyridine)
Boiling point 586.4±50.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
solubility Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Pyridine (Slightly, Sonicated)
form Solid
pka 11.99±0.70(Predicted)
color White to Off-White
FDA UNII AMW2MRV3OT

dichlorisone price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D431755 Dichlorisone 7008-26-6 25mg $180 2021-12-16 Buy
TRC D431755 Dichlorisone 7008-26-6 250mg $1390 2021-12-16 Buy
Product number Packaging Price Buy
D431755 25mg $180 Buy
D431755 250mg $1390 Buy

dichlorisone Chemical Properties,Uses,Production

Originator

Diloderm ,Schering,US,1960

Uses

Dichlorisone is a 9α,11β-dichloro corticoid. Dichlorisone has anti-antiinflammatory potency. Dichlorisone could be modifed to be used as glucocorticoid receptor agonists as well as a P-glycoprotein inhibitor.

Manufacturing Process

A solution of 1.0 g of 1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione-21- acetate and 5.0 g of lithium chloride in 40 ml of glacial acetic acid is treated
with 0.410 g of N-chlorosuccinimide, followed by 0.104 g of anhydrous hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture is stirred for 2 hours and poured into ice water. The crude product is filtered and washed with water to give 1.12 g of solid material, which is recrystallized from acetone-hexane to give substantially pure 9α,11β-dichloro-1,4- pregnadiene-17α,21-diol-3,20-dione-21-acetate; MP 246°C to 253°C (dec.).

Therapeutic Function

Antipruritic, Antihistaminic, Appetite stimulant

dichlorisone Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 7)Suppliers
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J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
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Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684; sales@rrkchem.com China 57423 58
Shaanxi Dideu Newmaterial Co., Ltd. 029-87576359 15353716720 1039@dideu.com China 10009 58
9,11β-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione Diloderm Disoderm (11β)-9,11-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione Pregna-1,4-diene-3,20-dione, 9,11-dichloro-17,21-dihydroxy-, (11β)- (8S,9R,10S,11S,13S,14S,17R)-9,11-dichloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one 7008-26-6 Intermediates & Fine Chemicals Pharmaceuticals Steroids