cis-4-Hydroxy-D-proline hydrochloride
- CAS No.
- 77449-94-6
- Chemical Name:
- cis-4-Hydroxy-D-proline hydrochloride
- Synonyms
- cis-D-Hyp-OH.HCl;H-D-cis-Hyp-OH.HCL;Cis-4-OH-D-pro-OH·HCl;CIS-4-HYDROXY-D-PROLINE HCL;D-Proline, 4-hydroxy-,hydrochloride;cis-4-Hydro×y-D-proline hydrochloride;cis-4-Hydroxy-D-proline hydrochloride;(2R,4R)-4-hydroxyproline hydrochloride;Cis-4-hydroxy-D-proline monohydrochloride;D-Proline, 4-hydroxy-,hydrochloride (1:1)
- CBNumber:
- CB1947559
- Molecular Formula:
- C5H10ClNO3
- Molecular Weight:
- 167.5908
- MDL Number:
- MFCD09749867
- MOL File:
- 77449-94-6.mol
| Melting point | 114-116 °C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| form | Solid |
| color | White to off-white |
| InChI | InChI=1/C5H9NO3.ClH/c7-3-1-4(5(8)9)6-2-3;/h3-4,6-7H,1-2H2,(H,8,9);1H/t3-,4-;/s3 |
| InChIKey | YEJFFQAGTXBSTI-QYDODFSFNA-N |
| SMILES | C(O)(=O)[C@H]1C[C@@H](O)CN1.[H]Cl |&1:3,5,r| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302-H315 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| HS Code | 29339900 |
cis-4-Hydroxy-D-proline hydrochloride price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H952393 | Cis-4-Hydroxy-D-prolinehydrochloride | 77449-94-6 | 500mg | $65 | 2021-12-16 | Buy |
| Matrix Scientific | 074556 | cis-4-Hydroxy-D-proline hydrochloride 95+% | 77449-94-6 | 5g | $121 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H58-5-4C | cis-4-Hydroxy-D-proline hydrochloride 97.0% | 77449-94-6 | 5G | $130 | 2021-12-16 | Buy |
| AK Scientific | J96651 | cis-4-Hydroxy-D-prolinehydrochloride | 77449-94-6 | 1g | $10 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H58-5-4C | cis-4-Hydroxy-D-proline hydrochloride 97.0% | 77449-94-6 | 25g | $190 | 2021-12-16 | Buy |
cis-4-Hydroxy-D-proline hydrochloride Chemical Properties,Uses,Production
Uses
Cis-4-Hydroxy-D-proline belongs to the class of organic compounds known as proline and derivatives. Proline and derivatives are compounds containing proline or a derivative thereof resulting from a reaction of proline at the amino group or the carboxyl group, or from the replacement of any hydrogen of glycine by a heteroatom. cis-4-Hydroxy-D-proline is a substrate that may be used to study the specificity and kinetics of D-alanine dehydrogenase.
Synthetic Application
Cis-4-Hydroxy-D-proline may be used as a starting material for the 13-step synthesis of new conformationally restricted PNA adenine monomer and the synthesis of N-Benzyl pyrrolidinyl sordaricin derivatives. Cis-4-Hydroxy-D-proline is a substrate that may be used to study the specificity and kinetics of D-alanine dehydrogenase. Cis-4-Hydroxy-D-proline may be used to analyze the substrate specificity of amino acid transporter PAT1.
Synthesis
A mixture of (2S,4R)-4-hydroxypyrrolidine-2-carboxylicacid(50 mmol, 6550 mg) and Ac2O (250 mmol, 23.5 mL) in AcOH (100 mL) wasstirred at reflux for 6 h. The resulting mixture was concentrated to give thecrude intermediate. The solution of this crude intermediate in 2 N HCl (50 mL)was stirred at reflux for 3 h. Then activated charcoal (1 g) was added, the hotmixture was ltered immediately through a Celite layer. The filtrate was concentrated in vacuo to give the crude intermediate.The crude intermediate was dissolved in acetone and filtered. The residue was washed twice with ether anddried in vacuo to give cis-4-Hydroxy-D-proline hydrochloride as a white solid (7.54 g, 90percent).
cis-4-Hydroxy-D-proline hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Chengdu Pukang Biotechnology Co., Ltd | 028-82550498 | export@pu-kang.com | CHINA | 210 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 11818 | 58 |
Related articles
- What is cis-4-Hydroxy-D-proline hydrochloride?
- cis-4-Hydroxy-D-proline is a substrate that may be used to study the specificity and kinetics of D-alanine dehydrogenase.D-pro....
- Feb 19，2020
View Lastest Price from cis-4-Hydroxy-D-proline hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-20 | cis-4-Hydroxy-D-proline hydrochloride
77449-94-6
|
US $1.00 / ASSAYS | 1ASSAYS | 97-99% | 1000KGS | Career Henan Chemical Co |
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- cis-4-Hydroxy-D-proline hydrochloride
77449-94-6
- US $1.00 / ASSAYS
- 97-99%
- Career Henan Chemical Co
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