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ChemicalBook >> CAS DataBase List >>Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl-

Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl-

Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- Structure
Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- structure
CAS No.
1613509-49-1
Chemical Name:
Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl-
Synonyms
SRI-41315;2-Cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione;Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl-
CBNumber:
CB19751092
Molecular Formula:
C22H19N3O2
Molecular Weight:
357.41
MDL Number:
MOL File:
1613509-49-1.mol
Last updated:2024-07-02 08:55:01
Request For Quotation

Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- Properties

Boiling point 495.3±55.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
pka 2.41±0.20(Predicted)
form Solid
color Light yellow to yellow

Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3312 SRI-41315 ≥95% (HPLC) 1613509-49-1 5MG $124 2024-03-01 Buy
Sigma-Aldrich SML3312 SRI-41315 ≥95% (HPLC) 1613509-49-1 25MG $500 2024-03-01 Buy
Product number Packaging Price Buy
SML3312 5MG $124 Buy
SML3312 25MG $500 Buy

Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- Chemical Properties,Uses,Production

Description

SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. SRI-41315 induce a prolonged pause at stop codons and suppress PTCs associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity.

Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- Preparation Products And Raw materials

Raw materials

Preparation Products

Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 3770 55
Aikon International Limited 025-66113011 18112977050 cb6@aikonchem.com China 15495 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
Dongyang Qiusuo Medical Technology Co., LTD 17502510579 2785299132@qq.com China 1558 58
Huayin Sample Biological Technology Co. LTD 13892502238 1453186328@qq.com China 500 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5012 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9274 58
Supplier Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Aikon International Limited 58
TargetMol Chemicals Inc. 58
Dongyang Qiusuo Medical Technology Co., LTD 58
Huayin Sample Biological Technology Co. LTD 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
RD International Technology Co., Limited 58
Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- SRI-41315 2-Cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione 1613509-49-1