ChemicalBook >> CAS DataBase List >>Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester
Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester
![Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester Structure](CAS/20211123/GIF/1821222-10-9.gif)
- CAS No.
- 1821222-10-9
- Chemical Name:
- Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester
- Synonyms
- Methyl [4-[(4-Fluorobenzyl)(2-propyn-1-yl)amino]-2,6-dimethylphenyl]carbamate;Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester
- CBNumber:
- CB19801137
- Molecular Formula:
- C20H21FN2O2
- Molecular Weight:
- 340.4
- MDL Number:
- MOL File:
- 1821222-10-9.mol
Last updated:2024-11-19 23:02:33
Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester Properties
| Boiling point | 452.2±45.0 °C(Predicted) |
|---|---|
| Density | 1.210±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 50 mg/mL (146.89 mM; Need ultrasonic) |
| pka | 13.39±0.70(Predicted) |
| form | Solid |
| color | Off-white to light yellow |
Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester Chemical Properties,Uses,Production
Biological Activity
HN37 as a potent and chemically stable antiepileptic drug candidate, with an EC50 of 37 nM for KCNQ2[1]. HN37 is a potent neuronal Kv7 activator with a subtype selectivity similar to RTG[1].
References
[1]. Yang-Ming Zhang, et al. Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate. J Med Chem. 2021 May 13;64(9):5816-5837.
Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester Suppliers
Global( 4)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19881 | 58 |
| Shaoyuan Technology (Shanghai) Co., Ltd. | 021-50795510 4000665055 | sy-c6@accelachem.com | China | 10073 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19699 | 58 |
| Supplier | Advantage |
|---|---|
| Aladdin Scientific | 58 |
| TargetMol Chemicals Inc. | 58 |
| Shaoyuan Technology (Shanghai) Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
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Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester
Methyl [4-[(4-Fluorobenzyl)(2-propyn-1-yl)amino]-2,6-dimethylphenyl]carbamate
1821222-10-9