ChemicalBook >> CAS DataBase List >>1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
- CAS No.
- 2353492-68-7
- Chemical Name:
- 1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
- Synonyms
- SIAIS164018;1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
- CBNumber:
- CB211375962
- Molecular Formula:
- C43H48ClN10O7P
- Molecular Weight:
- 883.33
- MDL Number:
- MOL File:
- 2353492-68-7.mol
Last updated:2023-07-14 17:43:39
1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- Chemical Properties,Uses,Production
Description
SIAIS164018 is a protein degrader. SIAIS164018 could degrade not only ALK fusion proteins in activating or G1202R-mutated form but also mutant EGFR with L858R + T790M, which are two most important targets in non-small-cell lung cancer. SIAIS164018 strongly inhibited cell migration and invasion of Calu-1 and MDA-MB-231. Surprisingly, SIAIS164018 degrades several important oncoproteins involved in metastasis such as FAK, PYK2, and PTK6. Interestingly, SIAIS164018 reshuffled the kinome ranking profile when compared to Brigatinib. SIAIS164018 is orally bioavailable and well tolerated in vivo. SIAIS164018 is an enlightening degrader for us to excavate the charm of protein degradation.
1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- Suppliers
Global( 1)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1381 | 58 |
Supplier | Advantage |
---|---|
Jilin Province Woda Biotechnology Co., Ltd. | 58 |
1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
SIAIS164018
2353492-68-7
C43H48ClN10O7P