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TTBK1-IN-2

TTBK1-IN-2 Structure
TTBK1-IN-2 structure
CAS No.
2765453-51-6
Chemical Name:
TTBK1-IN-2
Synonyms
TTBK1-IN-2;N-(4-(4-Chlorophenoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[4-(4-chlorophenoxy)phenyl]-
CBNumber:
CB211410968
Molecular Formula:
C18H13ClN4O
Molecular Weight:
336.77
MDL Number:
MOL File:
2765453-51-6.mol
Last updated:2024-07-02 08:55:01
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TTBK1-IN-2 Properties

Density 1.421±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (148.46 mM; ultrasonic and adjust pH to 2 with HCl)
pka 12.81±0.50(Predicted)
form Solid
color Off-white to light yellow

TTBK1-IN-2 Chemical Properties,Uses,Production

Biological Activity

TTBK1-IN-2 (compound 29) is a potent Tau-Tubulin kinase (TTBK1) inhibitor with IC50s of 0.24 and 4.22 μM, respectively. TTBK1-IN-2 reveals good brain penetration in vivo and is able to reduce TDP-43 phosphorylation not only in cell cultures but also in the spinal cord of transgenic TDP-43 mice[1].

References

[1]. Nozal V, et al. TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy. J Med Chem. 2022;65(2):1585-1607.

TTBK1-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

TTBK1-IN-2 Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 3717 55
Zhengzhou convergence chemical co., LTD 0371-0371-55153829 18003835034 2853979819@qq.com China 9273 58
Bide Pharmatech Ltd. 400-1647117 15221909166 product02@bidepharm.com China 63720 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9294 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12007 58
Supplier Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Zhengzhou convergence chemical co., LTD 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
RD International Technology Co., Limited 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
TTBK1-IN-2 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[4-(4-chlorophenoxy)phenyl]- N-(4-(4-Chlorophenoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 2765453-51-6