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TTBK1-IN-2

TTBK1-IN-2 Structure
TTBK1-IN-2 structure
CAS No.
2765453-51-6
Chemical Name:
TTBK1-IN-2
Synonyms
TTBK1-IN-2;N-(4-(4-Chlorophenoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[4-(4-chlorophenoxy)phenyl]-
CBNumber:
CB211410968
Molecular Formula:
C18H13ClN4O
Molecular Weight:
336.77
MDL Number:
MOL File:
2765453-51-6.mol
Last updated:2024-11-13 11:39:26
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TTBK1-IN-2 Properties

Density 1.421±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (148.46 mM; ultrasonic and adjust pH to 2 with HCl)
pka 12.81±0.50(Predicted)
form Solid
color Off-white to light yellow

TTBK1-IN-2 Chemical Properties,Uses,Production

Biological Activity

TTBK1-IN-2 (compound 29) is a potent Tau-Tubulin kinase (TTBK1) inhibitor with IC50s of 0.24 and 4.22 μM, respectively. TTBK1-IN-2 reveals good brain penetration in vivo and is able to reduce TDP-43 phosphorylation not only in cell cultures but also in the spinal cord of transgenic TDP-43 mice[1].

References

[1]. Nozal V, et al. TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy. J Med Chem. 2022;65(2):1585-1607.

TTBK1-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

TTBK1-IN-2 Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 4600 55
Zhengzhou convergence chemical co., LTD 0371-0371-55153829 18003835034 2853979819@qq.com China 9718 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62075 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24647 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 6813 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9272 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 13915962545 2881759498@qq.com China 2033 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12005 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Zhengzhou convergence chemical co., LTD 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
RD International Technology Co., Limited 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 58
Nanjing Shizhou Biology Technology Co.,Ltd 58

View Lastest Price from TTBK1-IN-2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TTBK1-IN-2 pictures 2024-11-12 TTBK1-IN-2
2765453-51-6
 US $74.00-252.00 / mg 99.83% 10g TargetMol Chemicals Inc.
  • TTBK1-IN-2 pictures
  • TTBK1-IN-2
    2765453-51-6
  • US $74.00-252.00 / mg
  • 99.83%
  • TargetMol Chemicals Inc.
TTBK1-IN-2 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[4-(4-chlorophenoxy)phenyl]- N-(4-(4-Chlorophenoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 2765453-51-6