1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]-
- CAS No.
- 2241676-74-2
- Chemical Name:
- 1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]-
- Synonyms
- SW222746;CAY10795;15-PGDH-IN-1;1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]-
- CBNumber:
- CB212282430
- Molecular Formula:
- C24H22N4O2
- Molecular Weight:
- 398.46
- MDL Number:
- MOL File:
- 2241676-74-2.mol
Boiling point | 665.1±55.0 °C(Predicted) |
---|---|
Density | 1.293±0.06 g/cm3(Predicted) |
solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml |
form | A crystalline solid |
pka | -0.94±0.30(Predicted) |
color | Light yellow to yellow |
1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]- Chemical Properties,Uses,Production
Description
CAY10795 is a 15-hydroxy prostaglandin dehydrogenase (15-PGDH) inhibitor (IC50 = 3 nM).1 It increases prostaglandin E2 (PGE2; ) levels greater than 3-fold in IL-1β-stimulated A549 human lung cells when used at a concentration of 500 nM. CAY10795 reduces 15-PGDH activity in the colon of mice when administered at a dose of 20 mg/kg and limits decreases in body weight and colon length and reduces colon ulceration in a mouse model of ulcerative colitis induced by dextran sodium sulfate (DSS; ) when administered at a dose of 40 mg/kg. It also accelerates recovery of circulating neutrophils following whole-body radiation and bone marrow transplant in mice when administered at a dose of 10 mg/kg twice per day.
References
1. Hu, B., Toda, K., Wang, X., et al. Orally bioavailable quinoxaline inhibitors of 15-
1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]- Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28091 | 58 |
Supplier | Advantage |
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TargetMol Chemicals Inc. | 58 |