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1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]-

1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]- structure

CAS No.: 2241676-74-2

Chemical Name:: 1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]-

Synonyms: SW222746;CAY10795;15-PGDH-IN-1;1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]-

CBNumber:: CB212282430

Molecular Formula:: C24H22N4O2

Molecular Weight:: 398.46

MDL Number:

MOL File:: 2241676-74-2.mol

Last updated:2024-07-02 08:55:02

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1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]- Properties

Boiling point	665.1±55.0 °C(Predicted)
Density	1.293±0.06 g/cm3(Predicted)
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml
form	A crystalline solid
pka	-0.94±0.30(Predicted)
color	Light yellow to yellow

1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]- Chemical Properties,Uses,Production

Description

CAY10795 is a 15-hydroxy prostaglandin dehydrogenase (15-PGDH) inhibitor (IC₅₀ = 3 nM).¹ It increases prostaglandin E₂ (PGE₂; ) levels greater than 3-fold in IL-1β-stimulated A549 human lung cells when used at a concentration of 500 nM. CAY10795 reduces 15-PGDH activity in the colon of mice when administered at a dose of 20 mg/kg and limits decreases in body weight and colon length and reduces colon ulceration in a mouse model of ulcerative colitis induced by dextran sodium sulfate (DSS; ) when administered at a dose of 40 mg/kg. It also accelerates recovery of circulating neutrophils following whole-body radiation and bone marrow transplant in mice when administered at a dose of 10 mg/kg twice per day.

References

1. Hu, B., Toda, K., Wang, X., et al. Orally bioavailable quinoxaline inhibitors of 15-prostaglandin dehydrogenase (15-PGDH) promote tissue repair and regeneration J. Med. Chem. 65(22),15327-15343(2022).

1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]- Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28091	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]- CAY10795 SW222746 15-PGDH-IN-1 2241676-74-2