Estramustine sodium phosphate
- CAS No.
- 52205-73-9
- Chemical Name:
- Estramustine sodium phosphate
- Synonyms
- emcyt;C13031;Estracyt;NSC 89199;iumphosphate;Ro 21-8837/001;estracytsodium;4-(550-Butyl)phenol;Estramustin sodium phosphate;ESTRAMUSTINE PHOSPHATE SODIUM
- CBNumber:
- CB2127417
- Molecular Formula:
- C23H33Cl2NNaO6P
- Molecular Weight:
- 544.38
- MDL Number:
- MFCD00866320
- MOL File:
- 52205-73-9.mol
| storage temp. | Inert atmosphere,2-8°C |
|---|---|
| solubility | H2O: soluble50mg/mL |
| form | A crystalline solid |
| color | White to off-white |
| Stability | Hygroscopic, Unstable in Solution |
| CAS DataBase Reference | 52205-73-9(CAS DataBase Reference) |
| FDA UNII | IQ856M1R16 |
| NCI Drug Dictionary | Emcyt |
Estramustine sodium phosphate price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E0407 | Estramustine sodium phosphate | 52205-73-9 | 25mg | $193 | 2024-03-01 | Buy |
| Sigma-Aldrich | E0407 | Estramustine sodium phosphate | 52205-73-9 | 5mg | $46.4 | 2023-06-20 | Buy |
| Cayman Chemical | 23126 | Estramustine Phosphate (sodium salt) ≥95% | 52205-73-9 | 10mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 23126 | Estramustine Phosphate (sodium salt) ≥95% | 52205-73-9 | 50mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 23126 | Estramustine Phosphate (sodium salt) ≥95% | 52205-73-9 | 100mg | $201 | 2024-03-01 | Buy |
Estramustine sodium phosphate Chemical Properties,Uses,Production
Description
Estramustine phosphate is a derivative of estradiol (Item Nos. 20776 | 10006315) that contains a nor-nitrogen mustard group. Estramustine phosphate destabilizes microtubules by binding to microtubule-associated proteins (MAPs) with Kd values of 10 and 15 μM for MAP-1 and MAP-2, respectively. Estramustine induces cell cycle arrest in mitosis at the metaphase stage in DU145 and PC3 prostate cancer cells and induces apoptosis in U87MG human malignant glioma cells. The metabolites of estramustine phosphate have anti-androgenic effects. Formulations containing estramustine phosphate are used in the palliative treatment of prostate cancer.
Uses
Estramustine phosphate sodium USP (Emcyt) is used to treat Prostatic carcinoma.
Uses
Antineoplastic.
Uses
Estramustine sodium phosphate is binds estradiol receptors irreversibly.
Definition
ChEBI: An organic sodium salt which is the disodium salt of estramustine phosphate.
brand name
Emcyt (Pharmacia & Upjohn).
General Description
Estramustine as the phosphate is available in 140-mg capsulesfor the treatment of prostate cancer. Although originallydesigned as an alkylating agent, it has been shown tobe devoid of alkylating activity and functions as an inhibitorof microtubule function by binding to microtubule associate proteins (MAPs) and also binds to tubulin at a site that isdistinct from that of the vinca alkaloids but thought to partiallyoverlap with that of pacilataxel.The major mechanismby which cells become resistant to the agent involvesincreased efflux, although this is not mediated by Pgp as isthe case with other microtubule inhibitors such as the taxanesand vinca alkaloids. Therefore, the agent does not showcross-resistance with these agents. As an inhibitor of microtubules,it is cell cycle specific acting in the M phase. Theagent is well absorbed upon oral administration with hydrolysisof the water solubilizing phosphate beginning to occurin the GI tract. Metabolism involves the formation of theactive estromustine, which arises from oxidation of the C17alcohol to give the ketone. Additional inactive metabolitesresult from carbamate hydrolysis to give estradiol and estrone.The parent and metabolites are primarily eliminatedin the feces with a terminal elimination half-life of 20 hours.The adverse effects of the agent are nausea and vomiting,which is generally mild but the severity may increase uponprolonged administration. Gynecomastia also commonlyoccurs, and diarrhea may also be seen. Less commonly seeneffects include myelosuppression, skin rash, and cardiovascularabnormalities including CHF.
Estramustine sodium phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29815 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34553 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23325 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15361 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
View Lastest Price from Estramustine sodium phosphate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-06 | Estramustine sodium phosphate USP/EP/BP
52205-73-9
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-01-08 | Estramustine sodium phosphate
52205-73-9
|
US $3.00 / KG | 1KG | 98% | 200KG | Career Henan Chemical Co |
-
- Estramustine sodium phosphate USP/EP/BP
52205-73-9
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Estramustine sodium phosphate
52205-73-9
- US $3.00 / KG
- 98%
- Career Henan Chemical Co