4-(4'-PHENOXYANILINO)-6,7-DIMETHOXYQUINAZOLINE
- CAS No.
- Chemical Name:
- 4-(4'-PHENOXYANILINO)-6,7-DIMETHOXYQUINAZOLINE
- Synonyms
- SRC KINASE INHIBITOR I;4-(4'-PHENOXYANILINO)-6,7-DIMETHOXYQUINAZOLINE;6,7-DIMETHOXY-N-(4-PHENOXYPHENYL)-4-QUINAZOLINAMINE;N-(6,7-DIMETHOXY-4-QUINAZOLINYL)-N-(4-PHENOXYPHENYL)AMINE
- CBNumber:
- CB2135739
- Molecular Formula:
- C22H19N3O3
- Molecular Weight:
- 373.4
- MDL Number:
- MFCD01815300
- MOL File:
- Mol file
4-(4'-PHENOXYANILINO)-6,7-DIMETHOXYQUINAZOLINE Chemical Properties,Uses,Production
Uses
Src Kinase inhibitor 1. The results showed that SKI-1 induced significant apoptosis in a dose-dependent manner in cancer cells with high basal Src activation. Src promotes survival and invasion of lung cancers with EGF receptor abnormalities and is a potential candidate for mol.-targeted therapy.
Biological Activity
Potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC 50 values are 44 and 88 nM for Src and Lck respectively). Inhibits VEGFR2 and c-fms at higher concentrations (IC 50 values are 0.32 and 30 μ M respectively). Can be used in parallel with PP 1 and PP 2 to inhibit Src family kinases.
4-(4'-PHENOXYANILINO)-6,7-DIMETHOXYQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-(4'-PHENOXYANILINO)-6,7-DIMETHOXYQUINAZOLINE Suppliers
Global( 23)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Bi Orange Blue Biotechnology Co., Ltd. | -- | bo49855987@163.com | CHINA | 6827 | 58 |
| Shanghai Yuqi Biological Technology Co., Ltd. | -- | 847627550@qq.com | CHINA | 6087 | 58 |
| Wuhan Boot Biotechnology Co., Ltd. | -- | CHINA | 6829 | 58 | |
| Shanghai Ziqi Biological Technology Co., Ltd. | -- | 2453006496@qq.com | CHINA | 6192 | 58 |
| Shanghai Haoran Biotechnology Co., Ltd. | -- | 470003480@QQ.COM | CHINA | 6968 | 58 |
| Jiangxi Jianglan Pure Biological Reagent Co., Ltd. | -- | 3245176082@qq.com | CHINA | 6136 | 58 |
| Beijing Boaolong Immunology Technology Co., Ltd. | -- | CHINA | 5676 | 58 | |
| Beijing Taize Jiaye Technology Development Co., Ltd. | -- | CHINA | 6050 | 58 | |
| Dongguan Biaobiao Experimental Equipment Technology Co., Ltd. | -- | CHINA | 6673 | 58 | |
| Morning Student Science and Technology (Guangzhou) Co., Ltd. | -- | chenxue_gz@163.com | CHINA | 6618 | 58 |
6,7-DIMETHOXY-N-(4-PHENOXYPHENYL)-4-QUINAZOLINAMINE
4-(4'-PHENOXYANILINO)-6,7-DIMETHOXYQUINAZOLINE
N-(6,7-DIMETHOXY-4-QUINAZOLINYL)-N-(4-PHENOXYPHENYL)AMINE
SRC KINASE INHIBITOR I