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dimebolin

dimebolin Structure
dimebolin structure
CAS No.
3613-73-8
Chemical Name:
dimebolin
Synonyms
CS-151;dimebon;Dimebone;dimebolin;Dimeboline;Brn 0622478;Latrepirdine;Preparation-84;DiMebon (latrepirdine);Dimebolin Exclusive
CBNumber:
CB21386820
Molecular Formula:
C21H25N3
Molecular Weight:
319.44
MDL Number:
MFCD00387540
MOL File:
3613-73-8.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33
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dimebolin Properties

Melting point 115-116 °C
Boiling point 448.46°C (rough estimate)
Density 1.13
refractive index 1.6380 (estimate)
storage temp. Store at -20°C
solubility ≤30mg/ml in ethanol;1mg/ml in DMSO;3mg/ml in dimethyl formamide
form crystalline solid
pka 9.05±0.20(Predicted)
CAS DataBase Reference 3613-73-8
EWG's Food Scores 1
FDA UNII OD9237K1Z6

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H320-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
NFPA 704
0
2 0

dimebolin price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 9000556 Dimebolin ≥98% 3613-73-8 1mg $21 2024-03-01 Buy
Cayman Chemical 9000556 Dimebolin ≥98% 3613-73-8 5mg $89 2024-03-01 Buy
Cayman Chemical 9000556 Dimebolin ≥98% 3613-73-8 10mg $157 2024-03-01 Buy
Cayman Chemical 9000556 Dimebolin ≥98% 3613-73-8 25mg $341 2024-03-01 Buy
Usbiological 255148 Dimebon dihydrochloride 3613-73-8 1mg $360 2021-12-16 Buy
Product number Packaging Price Buy
9000556 1mg $21 Buy
9000556 5mg $89 Buy
9000556 10mg $157 Buy
9000556 25mg $341 Buy
255148 1mg $360 Buy

dimebolin Chemical Properties,Uses,Production

Uses

Non-steroidal anti-inflammatory with analgesic and antipyretic effects

Definition

ChEBI: Latrepirdine is a member of methylpyridines and a pyridoindole. It has a role as a geroprotector.

Biological Activity

dimebolin is an orally-available antihistamine drug with a long history of clinical use in russia [1][2][3][4].dimebolin has been proposed to be useful for treating neurodegenerative disorders, including alzheimer's disease (ad) and huntington's disease (hd). dimebon might exhibit efficacy by blocking nmda receptors or voltage-gated ca2+ channels and by preventing mitochondrial permeability pore transition [3].dimebolin is an orally-available antihistamine drug. dimebon improved survival of cerebellar granule cells during long-term incubation with aβ25-35. dimebolin also blocked potential-dependent ca(2+) entry into neurons by about 20% by blocking l-type ca(2+) channels [4]. in the cerebellum cell culture, dimebolin protected neurons against the neurotoxic action of aβ25-35 with ec50 value of 25 μm. on isolated rat ileum intestine, dimebolin displayed ca2+-blocking properties with ic50 value of 57 μm. dimebon also exhibited anticholinesterase activity with ic50 values of 7.9 μm and 42 μm for butyryl-choline esterase and acetylcholine esterase, respectively [5].in rats treated with the neurotoxin af64a, dimebolin exhibited cognition and memory-enhancing properties. in mice, dimebolin prevented nmda-induced seizures with ec50 value of 42 ± 6 mg/kg [5].

References

[1]. lermontova nn, lukoyanov nv, serkova tp, et al. dimebon improves learning in animals with experimental alzheimer's disease. bull exp biol med. 2000 jun;129(6):544-6.
[2]. doody rs, gavrilova si, sano m, et al. effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate alzheimer's disease: a randomised, double-blind, placebo-controlled study. lancet. 2008 jul 19;372(9634):207-15.
[3]. wu j, li q, bezprozvanny i. evaluation of dimebon in cellular model of huntington's disease. mol neurodegener. 2008 oct 21;3:15.
[4]. lermontova nn, redkozubov ae, shevtsova ef, et al. dimebon and tacrine inhibit neurotoxic action of beta-amyloid in culture and block l-type ca(2+) channels. bull exp biol med. 2001 nov;132(5):1079-83.
[5]. bachurin s, bukatina e, lermontova n, et al. antihistamine agent dimebon as a novel neuroprotector and a cognition enhancer. ann n y acad sci. 2001 jun;939:425-35.

dimebolin synthesis

140-76-1
19686-05-6
3613-73-8
Synthesis of dimebolin from 2-Methyl-5-vinylpyridine and 2,8-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

dimebolin Preparation Products And Raw materials

Raw materials

2,8-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 2-Methyl-5-vinylpyridine

Preparation Products

dimebolin Suppliers

Global( 76)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22784 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Hebei Miaoyin Technology Co.,Ltd 		+86-17367732028 +86-17367732028 kathy@hbyinsheng.com China 3512 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
ZHIWE CHEMTECH CO LTD 021-20221225 13917446399 sales@zhiwe.net China 627 61
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Hubei Jusheng Technology Co.,Ltd. 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Hebei Miaoyin Technology Co.,Ltd 		58
Amadis Chemical Company Limited 		58
ZHIWE CHEMTECH CO LTD 61

View Lastest Price from dimebolin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dimebolin pictures 2024-11-19 Dimebolin
3613-73-8
 US $35.00-72.00 / mg 99.92% 10g TargetMol Chemicals Inc.
dimebolin pictures 2021-10-12 dimebolin
3613-73-8
 US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited
Latrepirdine pictures 2020-01-13 Latrepirdine
3613-73-8
 US $1.00 / g 1g 95-99% 1ton Career Henan Chemical Co
  • Dimebolin pictures
  • Dimebolin
    3613-73-8
  • US $35.00-72.00 / mg
  • 99.92%
  • TargetMol Chemicals Inc.
  • dimebolin pictures
  • dimebolin
    3613-73-8
  • US $1.10 / g
  • 99.00%
  • Dideu Industries Group Limited
  • Latrepirdine pictures
  • Latrepirdine
    3613-73-8
  • US $1.00 / g
  • 95-99%
  • Career Henan Chemical Co

3613-73-8(dimebolin)Related Search:

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3-Pyridineethaneamine dimebolin 2,8-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 2,5-Dimethylindole 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole
(1-Methyl-1H-indol-3-yl)-methylamine 1-METHYL-4,5,6,7-TETRAHYDRO-1H-PYRROLO[3,2-C]PYRIDINE 2-METHYL-3-N,N-DIMETHYLAMINOMETHYLINDOLE 2,3,4,5-TETRAHYDRO-8-METHYL-1H-PYRIDO[4,3-B]INDOLE 1H-PYRROLE-3-METHANAMINE, 1-METHYL-
RARECHEM AN KA 0161 METHYL-(5-METHYL-1H-INDOL-3-YLMETHYL)-AMINE 2-(6-METHYLPYRIDIN-3-YL)ETHANAMINE

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dimebolin 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indole 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole Dimeboline Dimebone Preparation-84 dimebon 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-1H-pyrido[4,3-b]indole 1H-Pyrido(4,3-B)indole, 2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-(6-methyl-3-pyridyl)ethyl)- 2,3,4,5-Tetrahydro-2,8-dimethyl-5-(2-(6-methyl-3-pyridyl)-ethyl)-1H-pyrid(4,3B)indole Brn 0622478 Dimebon dihydrochloride Dimebolin-Dihydrochloride 2,8-Dimethyl-5-[2-(6-methyl-pyridin-3-yl)-ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole Dimebolin 2,8-Dimethyl-5-[2-(6-methyl-pyridin-3-yl)-ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole DiMebon dihydrochloride hydrate 2,8-DiMethyl-5-[2-(6-Methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole DiMebon (latrepirdine) Latrepirdine dimebolin ISO 9001：2015 REACH 1H-Pyrido[4,3-b]indole, 2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]- Dimebolin Exclusive 2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole CS-151 3613-73-8