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(S)-(+)-3-Hydroxytetrahydrofuran

(S)-(+)-3-Hydroxytetrahydrofuran Structure
(S)-(+)-3-Hydroxytetrahydrofuran structure
CAS No.
86087-23-2
Chemical Name:
(S)-(+)-3-Hydroxytetrahydrofuran
Synonyms
(S)-TETRAHYDROFURAN-3-OL;(S)-3-HYDROXYTETRAHYDROFURAN;(3S)-oxolan-3-ol;(3S)-Tetrahydrofuran-3-ol;(S)-(-)-3-HYDROXY TETRAHYDRO FURAN;S-HTHF;Oxolane-3β-ol;(S)-Hydroxy THF;Afatinib intermediate;S-3- Hydroxytetrafuran
CBNumber:
CB2142463
Molecular Formula:
C4H8O2
Molecular Weight:
88.11
MDL Number:
MFCD00064327
MOL File:
86087-23-2.mol
MSDS File:
SDS
Last updated:2025-01-27 09:38:02
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(S)-(+)-3-Hydroxytetrahydrofuran Properties

alpha 18.5 º (c=2 MeOH)
Boiling point 80 °C/15 mmHg (lit.)
Density 1.103 g/mL at 25 °C (lit.)
vapor pressure 47Pa at 25℃
refractive index n20/D 1.45(lit.)
Flash point 175 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform, Methanol (Slightly)
pka 14.49±0.20(Predicted)
form Liquid
color Clear colorless to pale yellow
Specific Gravity 1.11
optical activity [α]20/D +17.5°, c = 2.4 in methanol
Water Solubility soluble
BRN 4652609
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey XDPCNPCKDGQBAN-BYPYZUCNSA-N
LogP -0.784 at 22℃ and pH6.8
Surface tension 72mN/m at 1g/L and 25℃
CAS DataBase Reference 86087-23-2(CAS DataBase Reference)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
RIDADR  NA 1993 / PGIII
WGK Germany  3
HS Code  29321900
NFPA 704
2
2 0

(S)-(+)-3-Hydroxytetrahydrofuran price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 296686 (S)-(+)-3-Hydroxytetrahydrofuran 99% 86087-23-2 5g $25.52 2024-03-01 Buy
Sigma-Aldrich 296686 (S)-(+)-3-Hydroxytetrahydrofuran 99% 86087-23-2 25g $104 2024-03-01 Buy
TCI Chemical T1716 (S)-3-Hydroxytetrahydrofuran >98.0%(GC) 86087-23-2 1g $16 2024-03-01 Buy
TCI Chemical T1716 (S)-3-Hydroxytetrahydrofuran >98.0%(GC) 86087-23-2 5g $38 2024-03-01 Buy
Alfa Aesar H56476 (S)-(+)-3-Hydroxytetrahydrofuran, 98% 86087-23-2 5g $77.65 2024-03-01 Buy
Product number Packaging Price Buy
296686 5g $25.52 Buy
296686 25g $104 Buy
T1716 1g $16 Buy
T1716 5g $38 Buy
H56476 5g $77.65 Buy

(S)-(+)-3-Hydroxytetrahydrofuran Chemical Properties,Uses,Production

Description

(S)-(+)-3-Hydroxytetrahydrofuran (3-OH THF) is a colorless liquid with a normal boiling point of 179 °C and boiling at 88-89 °C at 17 mmHg, with density (1.087 g/cm3 at 19 °C). 3-OH THF is a useful pharmaceutical intermediate. The chiral (absolute configuration S) version of this compound is an intermediate to launched retroviral drugs.

Chemical Properties

Colourless Liquid

Uses

(S)-(+)-3-Hydroxytetrahydrofuran is an intermediate to the AIDS drugs amprenavir and fosamprenavir. Additionally, it has been an intermediate to developmental drug substances, such as chemotherapy agents.

Uses

(S)-(+)-3-Hydroxytetrahydrofuran is a useful reagent for the preparation of pyrazolo triazin ylamine derivatives as adenosine receptor antagonists.

Synthesis

(S)-(+)-3-Hydroxytetrahydrofuran was prepared from the reaction of (S)-1,2,4-butanetriol under hydrochloric acid modified montmorillonite catalyst. The steps were as follows：To the heatable reactor (with stirring device), 100g (S)-1,2,4-butanetriol, 200mL toluene, 15g hydrochloric acid modified montmorillonite catalyst prepared in were added successively. The reaction was stopped after 4 h at 110°C. After the reaction is finished, it is naturally cooled to room temperature, and the obtained material is filtered to recover the catalyst. After collecting the filtrate, the remaining solvent and by-product water in the filtrate are distilled off to obtain (S)-3-hydroxytetrahydrofuran crude product. Quantitative analysis was carried out by gas chromatography, and the yield was 96.8%. Finally, the (S)-3-hydroxytetrahydrofuran was obtained by rectification and purification.S)-(+)-3-Hydroxytetrahydrofuran synthesis

(S)-(+)-3-Hydroxytetrahydrofuran Preparation Products And Raw materials

Raw materials

L-Malic acid p-Toluenesulfonic acid Ethanol Toluene Tetrahydrofuran
Ethyl acetate Lithium Aluminum Hydride Methanol

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Preparation Products

(R)-(-)-3-Hydroxytetrahydrofuran (S)-3-P-MESYLOXYTETRAHYDROFURAN (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

(S)-(+)-3-Hydroxytetrahydrofuran Suppliers

Global( 746)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou Ryan Pharmachem Technology Co.,Ltd.
+86-512-68780025 +8618962125825 sales@ryanchem.com China 136 58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd
027-88013699 17354350817 Ryan@jiutian-bio.com China 6001 58
Porton Pharma Solutions Ltd.
China 56 58
Lianhe Aigen Pharmatech Co.,Ltd.
+undefined+undefined18918657159 sales@lianhe-aigen.com China 316 58
Shanghai Yongzeng Technology Co.,Ltd
+8613818947575 sales@yongzchem.com China 140 58
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085 abby@weibangbio.com China 8804 58
Hebei Mujin Biotechnology Co.,Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12830 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531153977 allison@yan-xi.com China 5855 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5887 58
Shanghai Joiny Pharmaceutical Co.,LTD 		+8613681955282 gyd@joiny-pharma.com China 311 58
Supplier Advantage
Suzhou Ryan Pharmachem Technology Co.,Ltd.
58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd
58
Porton Pharma Solutions Ltd.
58
Lianhe Aigen Pharmatech Co.,Ltd.
58
Shanghai Yongzeng Technology Co.,Ltd
58
Hebei Weibang Biotechnology Co., Ltd 		58
Hebei Mujin Biotechnology Co.,Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Shanghai Joiny Pharmaceutical Co.,LTD 		58

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View Lastest Price from (S)-(+)-3-Hydroxytetrahydrofuran manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-(+)-3-Hydroxytetrahydrofuran pictures 2025-02-14 (S)-(+)-3-Hydroxytetrahydrofuran
86087-23-2
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
(S)-(+)-3-Hydroxytetrahydrofuran pictures 2025-02-12 (S)-(+)-3-Hydroxytetrahydrofuran
86087-23-2
 US $0.00 / KG 1KG 99% GC 100kg WUHAN FORTUNA CHEMICAL CO., LTD
(S)-(+)-3-Hydroxytetrahydrofuran pictures 2025-01-24 (S)-(+)-3-Hydroxytetrahydrofuran
86087-23-2
 US $0.00 / kg 1kg 98% 500kg Shanghai Joiny Pharmaceutical Co.,LTD

(S)-(+)-3-Hydroxytetrahydrofuran Spectrum

(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)MS(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)1HNMR(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)13CNMR(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)IR1(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)Raman

86087-23-2((S)-(+)-3-Hydroxytetrahydrofuran)Related Search:

Tetrahydrofuran 2-Methyltetrahydrofuran 3-(S)-HYDROXY TETRAHYDROFURAN 3-HYDROXYTETRAHYDROFURAN 99%,3-HYDROXYTETRAHYDROFURAN (RS)-3-Hydroxytetrahydrofuran
POLY(TETRAHYDROFURAN) STANDARD 15000 (R)-(+)-3-HYDROXYTETRAHYDROFURAN-2-ONE α-D-erythro-Pentofuranose-2-deoxy-2,2-difluoro-3,5-dibenzoate (S)-4-HYDROXYTETRAHYDROFURAN-2-ONE,4(S)-Hydroxytetrahydrofuran-2-ONE 3-HYDROXYTETRAHYDROFURAN-2-ONE,2-Hydroxytetrahydrofuran-2-one
(R)-(-)-3-HYDROXYTETRAHYDROFURAN,(R)-3-HYDROXYTETRAHYDROFURAN ((2R,3S,5R)-5-(5-(3-Aminopropyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate (S)-(+)-3-HYDROXYTETRAHYDROFURAN-D4 (3R)-3β,4α-Bis(3-methoxy-4-hydroxybenzyl)-3-hydroxytetrahydrofuran-2-one (2R, 4S)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL
(2R, 4R)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL (2S, 4S)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL 4-HYDROXYTETRAHYDROFURAN-2-METHANOL

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(S)-(+)-TETRAHYDRO-3-FURANOL (S)-(+)-3-HYDROXY TETAHYDRO FURAN (2S)-1,4-Epoxy-2-hydroxybutane, (3S)-Tetrahydrofuran-3-ol, (3S)-Oxolan-3-ol Afatinib intermediate B (S)-(+)-3-Hydroxytetrahydrofuran, ee: 95% Afatinib intermediate (S)-(+)-3-HydroxytetrahydrofuranZ (S)-(+)-3-Hydroxytetrahydrofuran 99% (S)-(+)-3-HYDROXYTETRAHYDROFURAN (S)-(+)-3-HYDROXYTETRAHYDROFURANE 3-FURANOL, TETRAHYDRO-, (S) (S)-(+)-3-HYDROXYTETRAHYDROFURAN, 99% (9 S-(+)-3-HYDROXYTETRAHYDROFURAN 98+% (S)-(+)-3-HYDOXY TETAHYDRO TETRAHYDRO FURAN (S)-3-Hydroxyterthydrofurane S-HYDROXYTETRAHYDROFURAN S-(+)-3-Hydroxytetrahydofuran (3S)-Tetrahydrofuran-3β-ol Oxolane-3β-ol (S)-(+)-3-Hydroxytetrahydrofuran,99% (S)-(+)-tetrahyro-3-furanol (S)-(+)-3-Hydroxytetrahydrofuran ,98% [ee:95%] (2S)-2-Hydroxy-1,4-epoxybutane (3S)-3-Hydroxytetrahydrofuran (S)-(+)-3-Hydroxytetrahydrofuran, 98% colorless liquid (S)-(+)-3-Hydroxytetrahydrofuran, 98%, ee: 95% (3S)-(+)-3-Hydroxytetrahydrofuran 97+% (S)-(+)-3-HYDROXYTETRAHYDROFURAN, (9 (S)-(+)-3-Hydroxy-1,2,3,4-tetrahydrofuran S-3-hydroxytetrahydrofur (S)-3-hydroxytetyrahydrofurane S-3- Hydroxytetrafuran 3-Furanol, tetrahydro-, (3S)- (S)-(+)-3-HYDROXYTETRAHYDROFURAN (CAS NO.86087-23-2) (S)-Hydroxy THF (3S)-Tetrahydrofuran-3-ol,(3S)-Oxolan-3-ol (+)-3-Hydroxy-1,2,3,4-Tetrahydrofuran (S)-TETRAHYDROFURAN-3-OL (S)-(-)-3-HYDROXY TETRAHYDRO FURAN (3S)-oxolan-3-ol (S)-3-HYDROXYTETRAHYDROFURAN (3S)-Tetrahydrofuran-3-ol Empagliflozin Impurity 100 (S)-3-hydroxytetyrahydrofuran (+)-3-Hydroxytetrahydrofuran S-HTHF 2,4-Dichlorobenzyl Alcohol Impurity 10 86087-23-2 86087-23-3 ALCOHOL Simple Alcohols (Chiral) Chiral Building Blocks Heterocyclic Building Blocks Furans Asymmetric Synthesis Afatinib intermediate Chiral Building Blocks Simple Alcohols (Chiral)