Alendronate sodium
- CAS No.
- 121268-17-5
- Chemical Name:
- Alendronate sodium
- Synonyms
- ALENDRONATE SODIUM TRIHYDRATE;Fosamax;Sodium alendronate trihydrate;MK-217;Bifosa;NeoBon;ADRONAT;Fosalan;Fosamsx;Alendros
- CBNumber:
- CB2145121
- Molecular Formula:
- C4H13NO7P2.3H2O.Na
- Molecular Weight:
- 326.13
- MDL Number:
- MFCD01748233
- MOL File:
- 121268-17-5.mol
| Melting point | 245°C |
|---|---|
| storage temp. | -20°C |
| solubility | water, double-distilled: 10 mg/mL |
| form | solid |
| color | white |
| Water Solubility | Soluble in water at 10mg/ml |
| Merck | 14,229 |
| Stability | Store in freezer |
| InChIKey | NKENDYHBVCKCNL-UHFFFAOYSA-M |
| CAS DataBase Reference | 121268-17-5(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | alendronate sodium; Fosamax |
| FDA UNII | 2UY4M2U3RA |
| NCI Drug Dictionary | alendronate sodium |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36-60 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SZ6523500 | |||||||||
| HS Code | 29310095 | |||||||||
| NFPA 704 |
|
Alendronate sodium price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 126855 | Alendronate, Sodium Salt | 121268-17-5 | 100mg | $239 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1012780 | Alendronate sodium United States Pharmacopeia (USP) Reference Standard | 121268-17-5 | 200mg | $436 | 2024-03-01 | Buy |
| TCI Chemical | A2456 | Alendronate Sodium Trihydrate >97.0%(T) | 121268-17-5 | 5g | $89 | 2024-03-01 | Buy |
| TCI Chemical | A2456 | Alendronate Sodium Trihydrate >97.0%(T) | 121268-17-5 | 25g | $267 | 2024-03-01 | Buy |
| Alfa Aesar | J61397 | Alendronate sodium trihydrate 97% | 121268-17-5 | 1g | $38.65 | 2024-03-01 | Buy |
Alendronate sodium Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Solid
Originator
Adronat ,Neopharmed ,Italy
Uses
Alendronate sodium trihydrate is used as a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor. A robust inhibitor of bone resorption that induces apoptosis. Alendronate inhibits the migration and invasion of PC-3 cells (sc-2220) by interfering with the mevalonate pathway. Additionally, Alendronate, Sodium Salt is an inhibitor of CD45RC and MMP.
Uses
Inhibits bone resorption and increases bone density.
Uses
dopamine receptor agonist, antiParkinsonian
Uses
A bisphosphonate used as a bone reabsoption inhibitor
Definition
ChEBI: A hydride that is the trihydrate of alendronate sodium
Manufacturing Process
4-Amino-1-hydroxybutylidene-1,1-diphosphonic acid (ABDT).
Orthosphophorous acid (102.7 g; 1.25 moles) is introduced into a 2 liter-flask
with condenser, stirrer and dropping funnel, placed on a thermostatized bath;
the air is then removed with a nitrogen stream which is continued during all
the reaction. The acid is melted by heating the bath to 95°C. When melting is
complete, 4-aminobutyric acid (103.3; 1 mole) is added under stirring which
is continued till obtaining a doughy fluid. Phosphorous trihalide (176 ml; 2
moles) is added dropwise causing the mixture to boil and evolution of gaseous
hydrochloric acid which is damped by means of a suitable trap. The addition
rate is adjusted so as to keep a constant reflux for about 60 minutes. When
the addition is nearly over, the mixture swells, slowly hardening. Stirring is
continued as long as possible, whereafter the mixture is heated for further 3
hours. Without cooling, but removing the bath, water (300 ml) is added, first
slowly and then quickly. Heating and stirring are started again. Decolorizing
charcoal is added and the mixture is boiled for about 5 minutes, then hotfiltered
on paper and the filtrate is refluxed for 6 hours. After cooling is slowly
poured in stirred methanol (1500 ml) causing thereby the separation of a
white solid which collected and dried (161 g; 64.6%). The structure of ABDT
is confirmed by IR spectrum, proton magnetic and nuclear magnetic
resonance spectrum and elemental analysis.
The sodium salt of this acid may be prepared by adding of equivalent of
sodium hydroxide.
brand name
Fosamax (Merck).
Therapeutic Function
Antiosteoporotic
General Description
Alendronate Sodium, an aminobisphosphonate compound, has been effectively used for the treatment of osteolysis, Paget′s disease and osteoporosis.
Biochem/physiol Actions
Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC50 = 460 nM); CD45 protein tyrosine phosphatase inhibitor.
Alendronate sodium Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12839 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18153 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Hebei Mojin Biotechnology Co.,Ltd | +86-15028179902 | angelia@hbmojin.com | China | 1177 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18775 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9206 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2986 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
View Lastest Price from Alendronate sodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-27 | Alendronate sodium
121268-17-5
|
US $0.00 / Kg/Drum | 1KG | 98.5%min HPLC | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-18 | Alendronate sodium
121268-17-5
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Weibang Biotechnology Co., Ltd | |
 |
2024-11-05 | Alendronate sodium
121268-17-5
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Weibang Biotechnology Co., Ltd |
-
- Alendronate sodium
121268-17-5
- US $0.00 / Kg/Drum
- 98.5%min HPLC
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Alendronate sodium
121268-17-5
- US $10.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
-
- Alendronate sodium
121268-17-5
- US $0.00-0.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
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