Methylene boldenone
- CAS No.
- 122370-91-6
- Chemical Name:
- Methylene boldenone
- Synonyms
- (17β)-;METHYLENE BOLDENONE;17--Hydroxy Exemestane;17β-Hydroxy Exemestane;Exemestane 17β-Hydroxy Impurity;17β-Hydroxy ExeMestane SulfaMate;Exemestane Impurity 23 (Exemestane EP Impurity H);(17)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one;(17b)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one;Androsta-1,4-dien-3-one, 17-hydroxy-6-methylene-, (17β)-
- CBNumber:
- CB21478037
- Molecular Formula:
- C20H26O2
- Molecular Weight:
- 298.42
- MDL Number:
- MOL File:
- 122370-91-6.mol
- MSDS File:
- SDS
| Melting point | 134-136°C |
|---|---|
| Density | 1.14 |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Off-White |
| CAS DataBase Reference | 122370-91-6 |
| FDA UNII | U35ZNO9DJH |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H361 | |||||||||
| Precautionary statements | P201-P202-P264-P280-P305+P351+P338-P308+P313-P337+P313-P405-P501 | |||||||||
| NFPA 704 |
|
Methylene boldenone price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27989 | 17β-hydroxy Exemestane | 122370-91-6 | 1mg | $263 | 2024-03-01 | Buy |
| Cayman Chemical | 27989 | 17β-hydroxy Exemestane | 122370-91-6 | 5mg | $848 | 2024-03-01 | Buy |
| TRC | H942345 | 17β-HydroxyExemestaneSulfamate | 122370-91-6 | 10mg | $1410 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 70677 | 17β-HydroxyExemestaneSulfamate | 122370-91-6 | 10mg | $2280 | 2021-12-16 | Buy |
| AK Scientific | 7621CS | MethyleneBoldenone, | 122370-91-6 | 5mg | $1043 | 2021-12-16 | Buy |
Methylene boldenone Chemical Properties,Uses,Production
Description
17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC50 = 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner. 17β-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.
Chemical Properties
Off-White Solid
Uses
A metabolite of Exemestane; exerts biological effects as an androgen.
Uses
17β-Hydroxy Exemestane Sulfamate is a metabolite of Exemestane (E957000).
Methylene boldenone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20342 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8615195660023 | sales@senfeida.com | China | 23046 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11922 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | 0755-66853366; 13670046396 | ORDERS@QCSRM.COM | China | 24326 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94657 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9679 | 58 |
| Cato Research Chemicals Inc. | 020-81960175 | min.he@cato-chem.com | China | 1955 | 55 |