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HA14-1

HA14-1 structure

CAS No.: 65673-63-4

Chemical Name:: HA14-1

Synonyms: HA14-1;CS-392;HA14-1/HA141;HA14-1 USP/EP/BP;HA14-1;HA-14-1; HA 14-1;HA14-1, Bcl-2 inhibitor. BH-3 mimetic.;ethyl 6-broMo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chroMene-3-carboxylate;[Ethyl 2-amino-6-bromo-4-(1cyano-2-ethoxy-2-oxoethyl)-4H-chromene3-3carboxylate];2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester;ETHYL [2-AMINO-6-BROMO-4-(1-CYANO-2-ETHOXY-2-OXOETHYL)]-4H-CHROMENE-3-CARBOXYLATE

CBNumber:: CB2170185

Molecular Formula:: C17H17BrN2O5

Molecular Weight:: 409.23

MDL Number:: MFCD00218213

MOL File:: 65673-63-4.mol

MSDS File:: SDS

Last updated:2024-11-19 20:33:22

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HA14-1 Properties

Melting point	105 °C
Density	1.480
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: 26 mg/mL
form	powder
color	White to light yellow
CAS DataBase Reference	65673-63-4

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319-H335

Precautionary statements

P280

Safety Statements

22-24/25

WGK Germany

HS Code

29322090

NFPA 704

	0
2		0

HA14-1 price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	14876	HA 14-1 ≥98%	65673-63-4	5mg	$25	2021-12-16	Buy
Cayman Chemical	14876	HA 14-1 ≥98%	65673-63-4	10mg	$48	2021-12-16	Buy
Cayman Chemical	14876	HA 14-1 ≥98%	65673-63-4	25mg	$113	2021-12-16	Buy
Cayman Chemical	14876	HA 14-1 ≥98%	65673-63-4	50mg	$163	2021-12-16	Buy
Tocris	1541	HA 14-1	65673-63-4	5	$72	2021-12-16	Buy

Product number	Packaging	Price	Buy
14876	5mg	$25	Buy
14876	10mg	$48	Buy
14876	25mg	$113	Buy
14876	50mg	$163	Buy
1541	5	$72	Buy

HA14-1 Chemical Properties,Uses,Production

Uses

HA14-1 is a cell-permeable, nonpeptidic Bcl-2 inhibitor.

Definition

ChEBI: 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylic acid ethyl ester is a 1-benzopyran.

Biological Activity

Cell-permeable inhibitor of Bcl-2 protein (IC 50 ~ 9 μ M); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells.

Biochem/physiol Actions

HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.

HA14-1 synthesis

Synthesis of HA14-1 from Ethyl cyanoacetate and 5-Bromosalicylaldehyde

HA14-1 Preparation Products And Raw materials

Raw materials

5-Bromosalicylaldehyde Ethyl cyanoacetate

Preparation Products

HA14-1 Suppliers

Global( 125)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22787	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58

View Lastest Price from HA14-1 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	HA14-1 65673-63-4	US $39.00-62.00 / mg		98%	10g	TargetMol Chemicals Inc.
	2019-07-06	HA14-1 65673-63-4	US $2.00 / kg	1kg	99%	100kg	Career Henan Chemical Co

HA14-1
65673-63-4
US $39.00-62.00 / mg
98%
TargetMol Chemicals Inc.

HA14-1
65673-63-4
US $2.00 / kg
99%
Career Henan Chemical Co

HA14-1 Spectrum

HA14-1(65673-63-4)MS HA14-1(65673-63-4)¹HNMR

65673-63-4(HA14-1)Related Search:

3-(5-BROMO-2-METHOXYPHENYL)PROPANOIC ACID ETHYL 2-CYANOVALERATE 3-(2-METHOXYPHENYL)PROPIONIC ACID 3-Phenylglutaric acid 3-(3-Bromophenyl)propionic acid

Ethyl 2-cyanopropanoate METHYL 3-(2-HYDROXYPHENYL)PROPIONATE 3-(3-BROMOPHENYL)PROPIONITRILE 3-(3-Bromophenyl)-2-methylprop-1-ene HA14-1

ETHYL 2-CYANOBUTANOATE 3-(2-HYDROXY-PHENYL)-PROPIONIC ACID ETHYL ESTER ethyl 2-cyano-3-phenyl-propanoate 3-(3-BROMO-PHENYL)-PROPAN-1-OL 2-CYANO-3-PHENYLPROPIONIC ACID

3-(5-bromo-2-methoxy-phenyl)propionitrile 2-Cyano-pentanedioic acid diethyl ester 3-(2-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

1of4

2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(4H)-1-benzopyrane-4-aceticacidethylester ethyl 6-broMo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chroMene-3-carboxylate 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester, Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate [Ethyl 2-amino-6-bromo-4-(1cyano-2-ethoxy-2-oxoethyl)-4H-chromene3-3carboxylate], Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester 2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphaR,4R)-rel-4H-1-benzopyran-4-acetic acid ethyl ester Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate 97% HA 14-1, Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate, 2-[2-Amino-6-bromo-3-(ethoxycarbonyl)-4H-chromen-4-yl]-3-ethoxy-3-oxopropanenitrile (R)-ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate 2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphaR,4R)-rel-4H-1-benzopyran-4-acetic acid ethyl ester HA 14-1 HA 14-1 2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphaR,4R)-rel-4H-1-benzopyran-4-acetic acid ethyl ester [Ethyl 2-amino-6-bromo-4-(1cyano-2-ethoxy-2-oxoethyl)-4H-chromene3-3carboxylate] Ethyl2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate97% HA14-1;HA-14-1; HA 14-1 ethyl (4S)-2-amino-6-bromo-4-[(R)-cyano-ethoxycarbonyl-methyl]-4H-chromene-3-carboxylate ETHYL [2-AMINO-6-BROMO-4-(1-CYANO-2-ETHOXY-2-OXOETHYL)]-4H-CHROMENE-3-CARBOXYLATE 2-AMINO-6-BROMO-ALPHA-CYANO-3-(ETHOXYCARBONYL)-4H-1-BENZOPYRAN-4-ACETIC ACID ETHYL ESTER HA14-1 Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate CS-392 4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-, ethyl ester, (αR,4R)-rel- HA14-1 USP/EP/BP rel-(R)-Ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate(relative) rel-Ethyl (αR,4R)-2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetate HA14-1/HA141 HA14-1, Bcl-2 inhibitor. BH-3 mimetic. 65673-63-4 C17H17BrN2O5 Apoptosis and Cell Cycle BioChemical Cell Biology Apoptosis Inducers Cell Signaling and Neuroscience Inhibitors Caspases/Apoptosis Inhibitor