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Cefozopran

CAS No.
113359-04-9
Chemical Name:
Cefozopran
Synonyms
D01052;Firstci;sce2787;SCE-1787;Firstcin);CEFOZOPRAN;Cefozopran (inn);SCE2787;SCE 2787;SCE-2787:Fastocin;Cefozopran(SCE 2787)
CBNumber:
CB2198495
Molecular Formula:
C19H17N9O5S2
Molecular Weight:
515.52
MDL Number:
MFCD00883679
MOL File:
113359-04-9.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17

Cefozopran Properties

Melting point >300°C
storage temp. Store at -20°C
solubility Soluble in DMSO
CAS DataBase Reference 113359-04-9(CAS DataBase Reference)
FDA UNII 1LG87K28LW
ATC code J01DE03

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H334-H317
Precautionary statements  P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501

Cefozopran price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific H710 Cefozopran 113359-04-9 5g $590 2021-12-16 Buy
American Custom Chemicals Corporation API0001903 CEFOZOPRAN 95.00% 113359-04-9 10G $2243.59 2021-12-16 Buy
AHH MT-49084 Cefozopran 98% 113359-04-9 0.5g $910 2021-12-16 Buy
DC Chemicals DC8067 Cefozopran(SCE2787) >98% 113359-04-9 250mg $1000 2021-12-16 Buy
Crysdot CD31004510 Cefozopran 98+% 113359-04-9 50mg $122 2021-12-16 Buy
Product number Packaging Price Buy
H710 5g $590 Buy
API0001903 10G $2243.59 Buy
MT-49084 0.5g $910 Buy
DC8067 250mg $1000 Buy
CD31004510 50mg $122 Buy

Cefozopran Chemical Properties,Uses,Production

Chemical Properties

White To Pale-Yellow Powder

Uses

Antibacterial

Definition

ChEBI: Cefozopran is a fourth-generation cephalosporin antibiotic having imidazo[1,2-b]pyridazin-1-ium-1-ylmethyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups located at positions 3 and 7 respectively. It is a cephalosporin, a member of thiadiazoles and an imidazopyridazine.

Antimicrobial activity

An aminothiazole cephalosporin formulated as the hydrochloride. Activity is similar to that of ceftazidime, but it is more active against methicillin-susceptible staphylococci (MIC 1 mg/L). Representative MICs against Gram-negative species are: Esch coli 0.25 mg/L; K. pneumoniae 1 mg/L; Ps. aeruginosa 1–8 mg/L. Activity against Acinetobacter spp., Sten. maltophilia and B. fragilis group is poor.
A 20-min infusion of 1.5 g achieved a plasma concentration of around 125 mg/L at the end of infusion. Almost 90% of the dose was excreted in the urine over 24 h. The mean terminal half-life was around 2 h. Adverse reactions appear to be typical of those of other group 6 cephalosporins.
It is available in Japan.

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CEFOZOPRAN sce2787 1-[[(6R,7R)-7-[[(2Z)-(5-Amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-imidazo[1,2-b]pyridazinium hydroxide inner salt 1-[[(6R,7R)-7-[[2Z)-(5-Amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]imidazo[1,2-b]pyridazinium Inner Salt Firstci SCE-1787 Cefozopran (inn) D01052 Firstcin) SCE-2787:Fastocin (6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl]amino]-3-(imidazo[2,3-f]pyridazin-4-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Parent nucleus of Cefozopran SCE2787;SCE 2787 Cefozopran(SCE 2787) Cefozopran USP/EP/BP 113359-04-9 C19H17N9O5S2 C19H18ClN9O5S2 Antibacterial Intermediates & Fine Chemicals Pharmaceuticals Cefozopran Hydrochloride and its intermediates