Nerolidol
- CAS No.
- 7212-44-4
- Chemical Name:
- Nerolidol
- Synonyms
- TRANS-NEROLIDOL;(E)-3,7,11-TRIMETHYL-1,6,10-DODECATRIEN-3-OL;nerolido;HuMbertiol;3,7,11-TRIMETHYL-1,6,10-DODECATRIEN-3-OL;1,6,10-dodecatrien-3-ol,3,7,11-trimethyl-;FCI-119b;FEMA 2772;Nerolidol;NerolidoI
- CBNumber:
- CB2206877
- Molecular Formula:
- C15H26O
- Molecular Weight:
- 222.37
- MDL Number:
- MFCD00008911
- MOL File:
- 7212-44-4.mol
| Melting point | -75 °C |
|---|---|
| Boiling point | 114 °C/1 mmHg (lit.) |
| Density | 0.875 g/mL at 25 °C (lit.) |
| vapor pressure | <1 hPa (20 °C) |
| refractive index |
n |
| FEMA | 2772 | NEROLIDOL (ISOMER UNSPECIFIED) |
| Flash point | 230 °F |
| storage temp. | Store below +30°C. |
| solubility | 0.014g/l, Very slightly soluble in water, soluble in alcohol and oils. |
| pka | 14.44±0.29(Predicted) |
| form | Liquid |
| color | Clear slightly yellow |
| Specific Gravity | 0.88 |
| Odor | at 100.00 %. floral green waxy citrus woody |
| Odor Type | floral |
| explosive limit | 0.7-4.5%(V) |
| Water Solubility | immiscible |
| Merck | 14,6476 |
| JECFA Number | 1646 |
| BRN | 1724135 |
| LogP | 4.5 at 24℃ |
| CAS DataBase Reference | 7212-44-4(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | NEROLIDOL |
| FDA UNII | QR6IP857S6 |
| NIST Chemistry Reference | 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-(7212-44-4) |
| EPA Substance Registry System | Nerolidol (7212-44-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H319-H410 | |||||||||
| Precautionary statements | P261-P264-P273-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,N | |||||||||
| Risk Statements | 36/37/38-50/53 | |||||||||
| Safety Statements | 26-36-61-60 | |||||||||
| RIDADR | UN 3082 9 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | JR4977000 | |||||||||
| F | 10-23 | |||||||||
| Autoignition Temperature | 230 °C | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29052290 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 5000 mg/kg | |||||||||
| NFPA 704 |
|
Nerolidol price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W277207 | Nerolidol mixture of cis and trans, ≥97%, stabilized, FG | 7212-44-4 | sample-k | $54.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | W277207 | Nerolidol mixtureofcisandtrans,≥97%,stabilized,FG | 7212-44-4 | 1kg | $250 | 2024-03-01 | Buy |
| Sigma-Aldrich | W277207 | Nerolidol mixtureofcisandtrans,≥97%,stabilized,FG | 7212-44-4 | 4kg | $800 | 2024-03-01 | Buy |
| Sigma-Aldrich | W277207 | Nerolidol mixtureofcisandtrans,≥97%,stabilized,FG | 7212-44-4 | 9kg | $1600 | 2024-03-01 | Buy |
| Sigma-Aldrich | H59605 | Nerolidol 98%, Mixture of cis and trans | 7212-44-4 | 25g | $61.5 | 2024-03-01 | Buy |
Nerolidol Chemical Properties,Uses,Production
Description
Nerolidol occurs naturally including the essential oil of neroli, ylang-ylang, and Peru balsam. It has a faint, fresh, unusually sweet, tenacious, floral odor similar to rose and apple. It can be used as a flavor ingredient in foods, such as baked goods, frozen dairy, nonalcoholic beverages, and soft candy. It is also used as fragrance in the perfumery.
References
[1] George A. Burdock, Fenaroli's Handbook of Flavor Ingredients, 6th Edition, 2010
Description
Nerolidol has a faint, floral odor similar to rose and apple. It is an unusually sweet, fresh, tenacious odor. The natural product can be dextro- or levo-rotatory, whereas the synthetic product is optically inactive; the double bond at positions 6-7 accounts for the cis- and trans-forms.
Chemical Properties
Clear slightly yellow liquid
Chemical Properties
Nerolidol has a faint, fresh, unusually sweet, tenacious, floral odor similar to rose and appe
Chemical Properties
Nerolidol is the sesquiterpene
analog of linalool. Because of the double bond at the 6-position, it exists as (6Z)- and (6E)- isomers, each forming an enantiomeric pair,
since the carbon atom in the 3-position is asymmetric.
Nerolidol is a component of many essential oils. (3S,6E)-(+)-nerolidol occurs in cabreuva oil.
Synthetic nerolidol consists of a mixture of racemic (6Z)- and (6E)-nerolidol
and is a colorless liquid with a long-lasting, mild floral odor.
Industrial synthesis of nerolidol starts with linalool, which is converted into
geranylacetone by using diketene, ethyl acetoacetate, or isopropenyl methyl
ether, analogously to the synthesis of 6-methyl-5-hepten-2-one from 2-methyl-
3-buten-2-ol. Addition of acetylene and partial hydrogenation of the resultant
dehydronerolidol produces a mixture of (6Z)- and (6E)-nerolidol racemates.Nerolidol is used as a base note in many delicate floral odor complexes. It is also
an intermediate in the production of vitamins E and K1.
Occurrence
Reported found in over 25 natural sources, including the essential oils of neroli, ylang-ylang, Peru balsam; in currant aroma; also reported in Dalbergia sissoo (60%, dl-), vervain, the distillation water of petitgrain bigarade, Helicrysum italicum, Myrocarpus frondosus and Myrocarpus fastigiatus (80%, d-), Tolu balsam, Acacia farnesiana, orange flower water, Paraguay petitgrain, jasmine, Melaleuca smithii and Melaleuca viridiflora. Also reported found in citrus peel oils and juices, guava, strawberry, peppermint and spearmint oil, pepper, milk powder, hop oil, beer, cognac, white wine, green tea, beans, mushroom, cardamom, rice, dill, corn oil, basil, wort, myrtle leaf, maté and mastic gum oil.
Uses
anti-ulcer, insect antifeedant
Uses
Nerolidol is one of the main component in the essential oils from fresh aerial parts of Thymus ciliatus (Lamiaceae). Also, it is a terpene that displays high potency on the contractility of cardiac muscle in guinea pig left atrium. A potential and effective treatment for malaria.
Preparation
1) From Geranylacetone plus Acetylene, followed by reduction of the acetylenic linkage (HotTmann-laRoche process).
2) by isolation from Cabreuva oil or other
essential oils.
Definition
ChEBI: Nerolidol is a farnesane sesquiterpenoid that is dodeca-1,6,10-triene which carries methyl groups at positions 3, 7 and 11 and a hydroxy group at position 3. It is a natural product that is present in various flowers and plants with a floral odor. Chemically, it exists in two geometric isomers, trans and cis forms. It is widely used in cosmetics (e.g. shampoos and perfumes), in non-cosmetic products (e.g. detergents and cleansers) and also as a food flavoring agent. It has a role as a flavouring agent, a cosmetic, a pheromone, a neuroprotective agent, an antifungal agent, an anti-inflammatory agent, an antihypertensive agent, an antioxidant, a volatile oil component, an insect attractant and a herbicide. It is a farnesane sesquiterpenoid, a tertiary allylic alcohol and a volatile organic compound.
Aroma threshold values
Detection: 10 ppb to 10 ppm
Taste threshold values
Taste characteristics at 25 ppm: green, floral, woody with fruity, citrus and melon nuances
General Description
Nerolidol is a naturally occurring sesquiterpene found in the essential oils.
Flammability and Explosibility
Non flammable
Synthesis
The natural product can be dextro- or levorotatory, whereas the synthetic product is optically inactive; the double bond at position 6 to 7 accounts for the cis- and trans-forms.
Nerolidol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12834 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5889 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
| JINING XINHE CHEMICAL CO., LTD | +8615318402391 | sales@xinhepharma.com | China | 809 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2930 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
Related articles
- Nerolidol: Properties, Production process and Uses
- Nerolidol is a fragrance ingredient used in a variety of flavor formulations. It is used in food and cosmetics.
- Mar 6，2024
View Lastest Price from Nerolidol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-23 | Nerolidol
7212-44-4
|
US $30.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-10-25 | Nerolidol
7212-44-4
|
US $1.00 / PCS | 1PCS | 99% | 10 mt | Hebei Weibang Biotechnology Co., Ltd | |
 |
2024-10-11 | Nerolidol
7212-44-4
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
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