Pagoclone
- CAS No.
- 133737-48-1
- Chemical Name:
- Pagoclone
- Synonyms
- PAGOCLONE;rac-Pagoclone;Pagoclone Labeled d4;2-(7-Chloro-2-naphthyridin-1,8-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one;2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone;1H-Isoindol-1-one, 2-(7-chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-
- CBNumber:
- CB22131049
- Molecular Formula:
- C23H22ClN3O2
- Molecular Weight:
- 407.89
- MDL Number:
- MFCD00864700
- MOL File:
- 133737-48-1.mol
- MSDS File:
- SDS
| Melting point | 173-179°C |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Pale Orange to Pale Red |
| FDA UNII | 38VAG2SA33 |
Pagoclone price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | P133845 | rac-Pagoclone | 133737-48-1 | 25mg | $400 | 2021-12-16 | Buy |
| TRC | P133845 | rac-Pagoclone | 133737-48-1 | 1mg | $50 | 2021-12-16 | Buy |
| Crysdot | CD11292281 | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one 97% | 133737-48-1 | 50mg | $396 | 2021-12-16 | Buy |
| Crysdot | CD11292281 | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one 97% | 133737-48-1 | 250mg | $1191 | 2021-12-16 | Buy |
| Chemtos | P-2470 | PagocloneLabeledd4 | 133737-48-1 | 10mg | $1680 | 2021-12-16 | Buy |
Pagoclone Chemical Properties,Uses,Production
Description
Pagoclone is a new cyclopyrrolone partial agonist. In animal models of antianxiety activity, pagoclone is more potent than benzodiazepines, is less sedating, and has a high therapeutic index (Table 29–1). In clinical studies, pagoclone is well tolerated and does not appear to cause sedation or affect psychomotor or cognitive performance. In studies of volunteers, it has been shown that it does not cause withdrawal symptoms on abrupt discontinuation after 14 days. These factors all suggest that pagoclone may be an important drug for the future. It is currently entering dose-ranging and comparative studies involving patients with anxiety disorders, and in a pilot crossover study, it reduced panic attacks; adverse effects were not different from or more numerous than those reported with placebo (Sandford et al. 1998).
Uses
Pagoclone is a partial GABAA agonist, used to reduce panic attacks and appear to decrease symptoms of generalized anxiety.
Uses
Anti-anxiety agent.
brand name
Bextra (Interneuron).
Side effects
Pagoclone is a novel cyclopyrrolone that acts as a partial GABAA receptor agonist. Preclinical studies suggest that pagoclone may have clinical utility as an anxiolytic agent, as well as a reduced incidence of side-effects. Pagoclone differs from benzodiazepines in that it does not emit a full electrophysiological response to GABA stimulation in vitro. Adverse events appear to be dose-related, with the most common side-effects reported as somnolence, dizziness, headache, asthenia, and lethargy, though cognitive effects have not yet been tested.
Pagoclone Preparation Products And Raw materials
Raw materials
Preparation Products
Pagoclone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 6813 | 58 |
| Supplier | Advantage |
|---|---|
| Alfa Chemistry | 58 |
| LEAPCHEM CO., LTD. | 58 |
| Amadis Chemical Company Limited | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 58 |