ChemicalBook CAS DataBase List Pagoclone

Pagoclone synthesis

9synthesis methods

Product Name:Pagoclone
CAS Number:133737-48-1
Molecular formula:C23H22ClN3O2
Molecular Weight:407.89

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100-52-7 Synthesis

100-52-7
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55243-02-2 Synthesis

55243-02-2
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133737-48-1
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$50.00/1mg

Yield:133737-48-1 15%

Reaction Conditions:

with dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer;copper diacetate in acetonitrile at 80; for 10 h;Schlenk technique;Inert atmosphere;

Steps:

1 Example 1

In a 25mL Schlenk bottle, 22 mg (0.2 mmol) of p-methylbenzaldehyde (1.0 eq), Cu(OAc) 2 65 mg (2.0 eq), 2-amino 1,8-naphthyridine 54 mg (1.5 eq), [Cp*RhCl2] 2 6 mg (5%). Then, it was evacuated and then purged with nitrogen. After three operations, 2 mL of acetonitrile and 50 mg of an unsaturated carbonyl compound (2.0 eq) were added, and the mixture was stirred at 80 ° C under a nitrogen atmosphere. After about 10 hours, the reaction was completed by TLC, a little silica gel was added, and the solvent was distilled off. Curing, solid loading, column chromatography. The total yield of pagoclone (cas: 133737-32-3) can be prepared to be about 15%.

References:

CN109485647,2019,A Location in patent:Paragraph 0029; 0030; 0031; 0032; 0033

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100-52-7 Synthesis

100-52-7
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