tert-Butyllithium

tert-Butyllithium Properties

Boiling point	36-40 °C
Density	0.69 g/mL at 20 °C
vapor density	~3 (vs air)
Flash point	20 °F
storage temp.	2-8°C
form	liquid
color	slightly cloudy
Sensitive	Air & Moisture Sensitive
BRN	3587204
Exposure limits	ACGIH: TWA 1000 ppm OSHA: TWA 1000 ppm(2950 mg/m3) NIOSH: IDLH 1500 ppm; TWA 120 ppm(350 mg/m3); Ceiling 610 ppm(1800 mg/m3)
InChIKey	BKDLGMUIXWPYGD-UHFFFAOYSA-N
CAS DataBase Reference	594-19-4(CAS DataBase Reference)
EPA Substance Registry System	Lithium, (1,1-dimethylethyl)- (594-19-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS07,GHS08,GHS09

Signal word

Danger

Hazard statements

H252-H318-H225-H250-H260-H304-H314-H336-H410-H411

Precautionary statements

P301+P310a-P303+P361+P353-P305+P351+P338-P405-P422a-P501a-P210-P222-P223-P231+P232-P370+P378-P422

Hazard Codes

F,C,N

Risk Statements

11-15-17-34-51/53-65-66-67-50/53-38-14/15

Safety Statements

26-36/37/39-43-45-62-61-16-33-9

RIDADR

UN 3394 4.2/PG 1

WGK Germany

1

F

3-10

TSCA

Yes

HazardClass

4.3

PackingGroup

I

HS Code

29319090

NFPA 704

	4
3		2
	W

tert-Butyllithium price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	186198	tert-Butyllithium solution 1.7M in pentane	594-19-4	4x25ml	$81.4	2024-03-01	Buy
Sigma-Aldrich	94439	tert-Butyllithium solution 1.6-3.2?M in heptane	594-19-4	100mL	$203	2024-03-01	Buy
Sigma-Aldrich	186198	tert-Butyllithium solution 1.7M in pentane	594-19-4	8l	$1490	2024-03-01	Buy
Alfa Aesar	044125	tert-Butyllithium nominally 1.5M in n-pentane	594-19-4	250ml	$104	2021-12-16	Buy
Alfa Aesar	041251	tert-Butyllithium, nominally 1.5M in n-pentane packaged under Argon in resealable ChemSeal? bottles	594-19-4	50ml	$27.5	2021-12-16	Buy

Product number	Packaging	Price	Buy
186198	4x25ml	$81.4	Buy
94439	100mL	$203	Buy
186198	8l	$1490	Buy
044125	250ml	$104	Buy
041251	50ml	$27.5	Buy

tert-Butyllithium Chemical Properties,Uses,Production

Description

tert-Butyllithium solution (tert-BuLi) is an organolithium compound, used as a strong base in organic chemistry. It facilitates lithium-halogen exchange reaction and also can be employed in the deprotonation of C-H compounds and amines. it has applications in organic synthesis since it is a strong base, capable of deprotonating many carbon molecules, including benzene. tert-Butyllithium is available commercially as hydrocarbon solutions; it is not usually prepared in the laboratory. Its synthesis was first reported by R. B. Woodward in 1941.

Chemical Properties

tert-Butyllithium is a colorless crystalline solid or colourless to pale yellow solution. It is more reactive than n- or sec-butyllithium and has similar properties. However, it is thermally stable. Dixon and co-workers have heated tert-Butyllithium to 100°C for 20 hr with little decomposition.

Uses

There are no commercial uses of t-butyllithium, but it is used as a polymerization initiator and as a metalating agent in the laboratory.
Alkylating and metalating agent. Reagent for the introduction of the tert-butyl group.
tert-Butyllithium (t-BuLi) is the most reactive of the commercially available organolithium reagents. It is supplied as a standard solution in hydrocarbon solvents, usually in a bottle sealed with a septum.

Application

tert-Butyllithium solution can be used as a strong base in the synthesis of:
Alkyllithium derivatives form alkyl iodides and diiodoalkanes by halogen-lithium exchange reaction.
Inorganic polymer [(LiMo3Se3)n] from [(InMo3Se3)n] by reductive intercalation method.
Adducts of cinnamic acid (1,3- and 1,4-adducts) by reacting with C-C double of cinnamic acid.

Preparation

tert-Butyllithium is not sold in large quantities. The industrial and laboratory preparations are the same: the reaction of t-butyl chloride with lithium metal in a hydrocarbon solvent. However, tert-Butyllithium is much more difficult to produce than the other isomeric butyllithium compounds and some special precautions must be taken to obtain good yields. Principally, the lithium metal must be finely divided and must contain several percent sodium. It has also been found that t-butyl alcohol in the butyl chloride is beneficial. The solvent of choice is pentane. Vigorous reflux is necessary for good yield since it apparently helps to remove lithium chloride from the surface of the metal, and pentane refluxes at about the optimum temperature. If hexane is used at the same temperature, a significantly lower yield is obtained.

tert-Butyllithium Preparation Products And Raw materials

Raw materials

2-Chloro-2-methylpropane Lithium Pentane

Preparation Products

Indole-5-carboxaldehyde 3-Bromofuran ETHYL 3-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE 3-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBONITRILE

(3-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANOL 5-CHLORO-3-METHYLBENZO[B]THIOPHENE-2-SULFONAMIDE 1-METHYL-1H-INDOLE-5-BORONIC ACID 2,2-DIMETHYL PROPANE DIOL-1,3-CYCLIC ESTER 3-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-AMINE Di-tert-butylchlorophosphane

Tri-tert-butylphosphine tetrafluoroborate 3-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-AMINE ORNOPROSTIL TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE 1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBALDEHYDE

(3-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANAMINE 3-METHOXY-PYRIDINE-2-CARBALDEHYDE tert-Butyldimethylsilyl chloride 5-Acetylindole 1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

(3-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL 3-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONITRILE 1-TERT-BUTYL-4-BROMO-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE Indole-4-boronic acid DI-TERT-BUTYLDICHLOROSILANE

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE (3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER 5-CHLORO-3-METHYLBENZO[B]THIOPHENE-2-SULFONYL CHLORIDE N-(6-FLUORO-3-FORMYLPYRIDIN-2-YL)PIVALAMIDE

4-BROMO-2-(TRIFLUOROMETHYL)-5-METHOXYPYRIDINE (1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANOL TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE ETHYL 1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 2-METHOXY-3-PYRIDINECARBOXALDEHYDE

5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE 3-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE Tri-tert-butylphosphine 1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-AMINE (1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANAMINE

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tert-Butyllithium Suppliers

Global( 215)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17365	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	7629	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shanghai UCHEM Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58

View Lastest Price from tert-Butyllithium manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-13	tert-Butyllithium 594-19-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	tert-Butyllithium 594-19-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	Tert-Butyllithium 594-19-4	US $1.00 / kg	1kg	99%	Customized	Career Henan Chemical Co

tert-Butyllithium
594-19-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

tert-Butyllithium
594-19-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Tert-Butyllithium
594-19-4
US $1.00 / kg
99%
Career Henan Chemical Co

594-19-4(tert-Butyllithium)Related Search:

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n-Butyllithium tert-Butylsulfinyl chloride Lithium hexamethyldisilazide Di-tert-butyl disulfide tert-Butanesulfinamide

METHYLLITHIUM AS COMPLEX WITH LITHIUM Ethyllithium Lithium Lithium hydride tert-Butyllithium

Methyllithium LITHIUM TERT-BUTYLCYCLOPENTADIENIDE ISOPROPYLLITHIUM

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TERT-BUTYLLITHIUM T-BUTYLLITHIUM tert-Butyllithium (ca. 18% in Pentane, ca. 1.9mol/L) (1,1-dimethylethyl)-lithiu tert-Butyllithium, 1.5M solution in pentane tert-butyllithium, nominally 1.5m in n-pentane, packaged under argon in resealable chemseal TERT-BUTYLLITHIUM 1.5M IN PENTANE tert-Butyllithium, nominally 1.5M in n-pentane, packaged under Argon in resealable ChemSealTM bottles tert-Butyllithium, nominally 1.5M in n-pentane, packaged under Argon in resealable ChemSeal bottles Lithium-2-methyl-2-propanide, t-BuLi TERT-BUTYLLITHIUM, 1.9M SOLUTION IN PENTANE tert-Butyllithium1.6M solution in pentaneAcroSeal§3 tert-Butyllithium, nominally 1.5M in n-pentane, packaged under Argon in resealable ChemSeal^t bottles LITHIUM TERT-BUTYL LITHIUM-2-METHYL-2-PROPANIDE tert-Butyllithium, 1.6M solution in pentane tert-Butyllithium, nominally 1.5M in n-pentane, packaged under Argon in resealable ChemSeal^t bottle ButyllithiuminpentaneMslightlycloudyliq t-Butyllithium 16% in pentane (1-2M) tert-Butyllithium solution TERT-BUTYLLITHIUM SOLUTION, ~1.5 M IN PE NTANE TERT-BUTYLLITHIUM SOLUTION IN HEPTANE TERT-BUTYLLITHIUM, 1.7M SOLUTION IN PENT Nominally1.5Minn-Pentane packagedunderArgoninresealableChemSealbottles tert-Butyllithium,nominally1.5Minn-pentane TERT-BUTYLLITHIUM 1.7 M IN PENTANE T-BuLi1.7Msolutioninpentane tert-Butyllithium (ca. 16% in Pentane, ca. 1.6mol/L) tert-Butyllithium,1.3M in pentane (1,1-Dimethylethyl)lithium (1,1-dimethylethyl)-Lithium 1,1-Dimethyl-ethane-lithium Lithium,(1,1-dimethylethyl)- tert-Butyllithium, 1.9M solution in pentane, AcroSeal tert-Butyllithium, 1.6M solution in pentane, AcroSeal tert-ButyllithiuM, 1.6M solution in pentane, AcroSeal 800ML tert-ButyllithiuM, 18% solution in heptane, AcroSeal tert-ButyllithiuM, solution in pentane tert-ButyllithiuM, 1.3 M solution in pentane tert-ButyllithiuM, 1.3 M solution in pentane, J&KSeal tert-ButyllithiuM, 1.3 M solution in Pentane, SpcSeal tert-Butyllithium solution, 1.5M in n-pentane Tert butyl lithium 1.3m n-pentane tert-Butyllithium, 1.6 M solution in pentane, J& tert-Butyllithium, for synthesis, 1.3 M in pentane, J& tert-Butyllithium ISO 9001：2015 REACH Copper - titanium (1:1) C4H9Li TERT-BUTYLLITHIUM 594-19-4 T-BULI tert-Butyllithium, 1.5M in n-pentane 594-19-4 CH33CLi Alkyl Organolithium Organometallic Reagents metal alkyl