RS 23597-190 HYDROCHLORIDE
- CAS No.
- 149719-06-2
- Chemical Name:
- RS 23597-190 HYDROCHLORIDE
- Synonyms
- RS23597-190HCl;RS 23597-190 hydroch;RS 23597-190 >=98% (HPLC);RS 23597-190 HYDROCHLORIDE;RS 23597 190 hydrochloride,RS 23597190 hydrochloride;3-(PIPERIDIN-1-YL)PROPYL-4-AMINO-5-CHLORO-2-METHOXYBENZOATE HCL;3-(PIPERIDIN-1-YL)PROPYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE HYDROCHLORIDE;3-piperidin-1-ylpropyl 4-azanyl-5-chloro-2-methoxy-benzoate hydrochloride;3-(piperidine-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride;4-amino-5-chloro-2-methoxy-benzoic acid 3-piperidinopropyl ester hydrochloride
- CBNumber:
- CB2242093
- Molecular Formula:
- C16H24Cl2N2O3
- Molecular Weight:
- 363.28
- MDL Number:
- MFCD00672672
- MOL File:
- 149719-06-2.mol
- MSDS File:
- SDS
RS 23597-190 HYDROCHLORIDE price More Price(13)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1909 | RS 23597-190 ≥98% (HPLC) | 149719-06-2 | 5MG | $102 | 2023-06-20 | Buy |
Sigma-Aldrich | SML1909 | RS 23597-190 ≥98% (HPLC) | 149719-06-2 | 25MG | $376 | 2022-05-15 | Buy |
Tocris | 0728 | RS23597-190hydrochloride | 149719-06-2 | 50 | $411 | 2021-12-16 | Buy |
Tocris | 0728 | RS23597-190hydrochloride | 149719-06-2 | 10 | $98 | 2021-12-16 | Buy |
TRC | R700958 | RS23597-190Hydrochloride | 149719-06-2 | 5mg | $420 | 2021-12-16 | Buy |
RS 23597-190 HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
RS 23597-190 Hydrochloride is a selective and competitive SR-4 and 5-HT4 receptor antagonist.
Biological Activity
A high affinity, selective competitive antagonist at 5-HT 4 receptors.
Biochem/physiol Actions
RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy. RS 23597-190 is a 4-amino-5-chloro-2-methoxybenzoate that antagonizes 5-HT-mediated relaxation of carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pA2 = 7.5) and prevents 5-HT-induced tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (6 mg/kg RS 23597-190 and 3-10 μ/kg 5-HT via i.v.) by targeting 5-HT4 with high affinity (pKB = 7.8) and selectivity, while exhibiting no efficacy against 5-methoxytryptamine-mediated 5-HT3 activation in guinea-pig ileum and displaying much reduced or little affinity toward 5-HT3 (pKi = 5.7/mouse NG108-15 cells and pKB <5/guinea-pig ileum), dopamine receptors (pKi <4/D1 & <3/D2), muscarinic receptors (pKi <4.5 toward M1/2/3/4), 5-HT1A & 5-HT2 (pKi <5.2).
storage
Store at RT
RS 23597-190 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
RS 23597-190 HYDROCHLORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 19169 | 64 |
Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | market@aladdin-e.com | China | 25009 | 65 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
Beijing Haite lesk Technology Co., Ltd | 15210893940; 15116916250 | chemistryliu@163.com | China | 7329 | 58 |
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