| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:RS 23597-190 hydrochloride;3-(Piperidin-1-yl)propyl4-aMino-5-chloro-2-Methoxybenzoatehydrochloride
CAS:149719-06-2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | RS 23597-190 HYDROCHLORIDE Basic information |
| Product Name: | RS 23597-190 HYDROCHLORIDE | | Synonyms: | 3-(PIPERIDIN-1-YL)PROPYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE HYDROCHLORIDE;RS 23597-190 HYDROCHLORIDE;RS23597-190HCl;3-(piperidine-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride;3-piperidin-1-ylpropyl 4-azanyl-5-chloro-2-methoxy-benzoate hydrochloride;4-amino-5-chloro-2-methoxy-benzoic acid 3-piperidinopropyl ester hydrochloride;3-(PIPERIDIN-1-YL)PROPYL-4-AMINO-5-CHLORO-2-METHOXYBENZOATE HCL;4-amino-5-chloro-2-methoxybenzoic acid 3-(1-piperidinyl)propyl ester hydrochloride | | CAS: | 149719-06-2 | | MF: | C16H24Cl2N2O3 | | MW: | 363.28 | | EINECS: | | | Product Categories: | | | Mol File: | 149719-06-2.mol |  |
| | RS 23597-190 HYDROCHLORIDE Chemical Properties |
| storage temp. | Sealed in dry,2-8°C | | solubility | Water:36.33(Max Conc. mg/mL);100.0(Max Conc. mM) | | form | Powder | | color | White to off-white | | Water Solubility | Soluble to 100 mM in water |
| | RS 23597-190 HYDROCHLORIDE Usage And Synthesis |
| Uses | RS 23597-190 Hydrochloride is a selective and competitive SR-4 and 5-HT4 receptor antagonist. | | Biological Activity | A high affinity, selective competitive antagonist at 5-HT 4 receptors. | | Biochem/physiol Actions | RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy. RS 23597-190 is a 4-amino-5-chloro-2-methoxybenzoate that antagonizes 5-HT-mediated relaxation of carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pA2 = 7.5) and prevents 5-HT-induced tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (6 mg/kg RS 23597-190 and 3-10 μ/kg 5-HT via i.v.) by targeting 5-HT4 with high affinity (pKB = 7.8) and selectivity, while exhibiting no efficacy against 5-methoxytryptamine-mediated 5-HT3 activation in guinea-pig ileum and displaying much reduced or little affinity toward 5-HT3 (pKi = 5.7/mouse NG108-15 cells and pKB <5/guinea-pig ileum), dopamine receptors (pKi <4/D1 & <3/D2), muscarinic receptors (pKi <4.5 toward M1/2/3/4), 5-HT1A & 5-HT2 (pKi <5.2). | | storage | Store at RT |
| | RS 23597-190 HYDROCHLORIDE Preparation Products And Raw materials |
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