(-)-INDOLACTAM V
- CAS No.
- 90365-57-4
- Chemical Name:
- (-)-INDOLACTAM V
- Synonyms
- (-)-Ilv;IndolactaM;Brn 4711877;()-Indolactam V;(-)-Indolactam V;(-)-Indolactam V (-)-Indolactam V/Indolactam V;()Indolactam V,( ) Indolactam V;(-)-Indolactam V, PKC activator;(2s-(2r*,5r*))-ethyl)-1-methyl-2-(1-methylethyl)
- CBNumber:
- CB2244996
- Molecular Formula:
- C17H23N3O2
- Molecular Weight:
- 301.38
- MDL Number:
- MFCD00151197
- MOL File:
- 90365-57-4.mol
| Boiling point | 584.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.166±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: >10mg/mL, clear |
| form | white powder |
| pka | 14.39±0.10(Predicted) |
| color | White to light yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| FDA UNII | 8CIY9O1323 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313 |
| WGK Germany | 3 |
| RTECS | UY8547000 |
(-)-INDOLACTAM V price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I0661 | (?)-Indolactam V ≥96% (HPLC) | 90365-57-4 | 1mg | $354 | 2024-03-01 | Buy |
| Cayman Chemical | 14647 | (-)-Indolactam V ≥95% | 90365-57-4 | 500μg | $158 | 2024-03-01 | Buy |
| Cayman Chemical | 14647 | (?)-Indolactam V ≥97% | 90365-57-4 | 1mg | $299 | 2024-03-01 | Buy |
| Cayman Chemical | 14647 | (?)-Indolactam V ≥97% | 90365-57-4 | 300μg | $120 | 2021-12-16 | Buy |
| TRC | I577325 | (-)-IndolactamV | 90365-57-4 | 10mg | $4195 | 2021-12-16 | Buy |
(-)-INDOLACTAM V Chemical Properties,Uses,Production
Description
Indolactam V (-) (90365-57-4) is a PKC activator acting at the phorbol ester binding site.1,2?Directs differentiation of human and mouse ESCs to pancreatic cells.3?? May be used, along with other agents, to differentiate human iPS cells into glucose-responsive insulin-secreting progeny.4?Increases regulator of G protein signaling 2 (RGS2) protein levels, a protein that regulates GPCR signaling.5
Uses
(-)-Indolactam V is an indole alkaloid compound which activates protein kinase C (PKC). Weak tumor promoter. Also directs differentiation of human embryonic stem cells, potentially into pancreatic lineage allowing for an effective diabetes therapy.
Definition
ChEBI: (-)-indolactam V is a 9-membered ring that is a potent protein kinase C activator
Biological Activity
Protein kinase C activator. Exhibits tumor promoting activity. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors.
Biochem/physiol Actions
(-)-Indolactam V is a PKC activator shown to effect differentiation in embryonic stem cells leading to development of pancreatic precursors. It is active in the mouse model.
storage
-20°C (desiccate)
References
1) Fujiki?et al.?(1984),?Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin; Gan., 75?866 2) Heikkila and Ackerman (1989),?(-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells; Biochem. Biophys. Res. Commun,?162?1207 3) Chen?et al.?(2009),?A small molecule that directs differentiation of human ESCs into the pancreatic lineage; Nat. Chem. Biol.,?5?258 4) Thalava?et al. (2011),?Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secretin progeny; Gene Ther.,?18?283 5) Raveh (2014),?Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts; Mol. Pharmacol.,?86?406
(-)-INDOLACTAM V Preparation Products And Raw materials
Raw materials
Preparation Products
(-)-INDOLACTAM V Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32222 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7787 | 56 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4660 | 60 |
View Lastest Price from (-)-INDOLACTAM V manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | (-)-Indolactam V
90365-57-4
|
US $748.00 / mg | 10g | TargetMol Chemicals Inc. |
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- (-)-Indolactam V
90365-57-4
- US $748.00 / mg
- TargetMol Chemicals Inc.