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PF-4708671

PF-4708671 Structure
PF-4708671 structure
CAS No.
1255517-76-0
Chemical Name:
PF-4708671
Synonyms
CS-869;PF 4708671;PF-04708671;PF4708671/PF-4708671;PF-4708671 USP/EP/BP;PF 4708671 - PF 04708671;PF-4708671 PF4708671 S6 kinase inhibitor;2-[[4-(5-ethyl-4-pyriMidinyl)-1-piperazinyl]Methyl]-6-(trifluoroMethyl)-1H-benziMidazole;2-[[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-6-(trifluoromethyl)-1H-benzimidazole;1H-Benzimidazole, 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-
CBNumber:
CB22518730
Molecular Formula:
C19H21F3N6
Molecular Weight:
390.41
MDL Number:
MFCD18086922
MOL File:
1255517-76-0.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33
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PF-4708671 Properties

Boiling point 572.8±50.0 °C(Predicted)
Density 1.348±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: ≥20mg/mL
form powder
pka 10.20±0.10(Predicted)
color off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P302+P352-P305+P351+P338-P362+P364
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  2933599590
NFPA 704
0
2 0

PF-4708671 price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0143 PF-4708671 ≥98% (HPLC) 1255517-76-0 5mg $134 2024-03-01 Buy
Sigma-Aldrich PZ0143 PF-4708671 ≥98% (HPLC) 1255517-76-0 25mg $545 2024-03-01 Buy
Cayman Chemical 15018 PF-04708671 ≥98% 1255517-76-0 10mg $93 2024-03-01 Buy
Cayman Chemical 15018 PF-04708671 ≥98% 1255517-76-0 25mg $218 2024-03-01 Buy
Cayman Chemical 15018 PF-04708671 ≥98% 1255517-76-0 50mg $412 2024-03-01 Buy
Product number Packaging Price Buy
PZ0143 5mg $134 Buy
PZ0143 25mg $545 Buy
15018 10mg $93 Buy
15018 25mg $218 Buy
15018 50mg $412 Buy

PF-4708671 Chemical Properties,Uses,Production

Chemical Properties

Pale purple Solid

Uses

PF-4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). PF-4708671 inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect on highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.

Biological Activity

pf-4708671 is a cell-permeable and highly specific inhibitor of p70 ribosomal s6 kinase 1 with ic50 value of 160nm [1].s6k1 is a regulator of various biology processes. the inhibition of s6k1 is regard as a therapeutic for the treatment of cancer and insulin resistance. pf-4708671 is the first reported inhibitor of s6k1. it inhibits the activity of s6k1 in the in vitro assay with ki value of 20nm. for the isolated s6k1 from hek293 cell, pf-4708671 shows inhibition with ic50 value of 160nm. the inhibition of s6k1caused by pf-4708671 is much more potent than of other related kinases such as rsk2 and msk1. besides that, pf-4708671 prevents s6k1 from phosphorylating its substrates including the ribosomal s6 protein, mtor and rictor. in addition, pf-4708671 is found to enhance the phosphorylation of s6k1 at thr229 and thr389, results in a subsequent increase of s6k1 activity. whereas this increased activity is much less than that stimulated by igf1 [1].

Biochem/physiol Actions

PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor. PF-4708671 inhibits S6K1 with a Ki of 20 nM and IC50 of 160 nM, while having no effect on the closely related RSK and MSK kinases.

Enzyme inhibitor

This cell-permeable protein kinase inhibitor (FW = 390.41 g/mol; CAS 1255517-76-0; Solubility = 30 mg/mL DMSO, <1 mg/mL H2O) targets p70 ribosomal S6 kinase (S6K1 isoform) with Ki of 20 nM and IC50 of 160 nM, without significant inhibition of S6K2 isoform or Akt1, Akt2, PKA, PKCα, PKC?, PRK2, ROCK2, RSK1, RSK2, or SGK1. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMAinduced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.

storage

Store at +4°C

References

[1] pearce l, alton g, richter d, et al. characterization of pf-4708671, a novel and highly specific inhibitor of p70 ribosomal s6 kinase (s6k1). biochem. j, 2010, 431: 245-255.

PF-4708671 Preparation Products And Raw materials

Raw materials

Preparation Products

PF-4708671 Suppliers

Global( 132)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29881 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22883 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574 info@chemia-pharm.com CHINA 311 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Biochempartner 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
Chemia Biotechnology（Shanghai） Co., Ltd 		58
Zhejiang J&C Biological Technology Co.,Limited 		58

View Lastest Price from PF-4708671 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PF-4708671 pictures 2024-11-19 PF-4708671
1255517-76-0
 US $47.00-113.00 / mg 99.67% 10g TargetMol Chemicals Inc.
2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole pictures 2019-07-06 2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole
1255517-76-0
 US $2.00 / kg 1kg 99% ask Career Henan Chemical Co
  • PF-4708671 pictures
  • PF-4708671
    1255517-76-0
  • US $47.00-113.00 / mg
  • 99.67%
  • TargetMol Chemicals Inc.

PF-4708671 Spectrum

PF-4708671(1255517-76-0)1HNMR

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1of3

2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole PF 4708671 PF4708671/PF-4708671 2-[[4-(5-ethyl-4-pyriMidinyl)-1-piperazinyl]Methyl]-6-(trifluoroMethyl)-1H-benziMidazole PF-04708671 1H-Benzimidazole, 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)- 2-[[4-(5-Ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole PF-4708671 2-[[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-6-(trifluoromethyl)-1H-benzimidazole CS-869 PF 4708671 - PF 04708671 PF-4708671 USP/EP/BP 2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-6-(trifluoromethyl)-1H-benzo[d]imidazole PF-4708671 PF4708671 S6 kinase inhibitor 1255517-76-0 C19H21F3N6 Akt mTOR PI3K PI3K/Akt/mTOR Amines Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pfizer Compounds Pharmaceuticals API