Silybin
- CAS No.
- 802918-57-6
- Chemical Name:
- Silybin
- Synonyms
- Silybin A,B (Mixture);Silybin (Mixture of Diastereomers);(2R,3R)-3,5,7-Trihydroxy-2-(3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one;(2R,3R)-3,5,7-Trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-o ne;4H-1-Benzopyran-4-one, 2-[2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-
- CBNumber:
- CB22545743
- Molecular Formula:
- C25H22O10
- Molecular Weight:
- 482.44
- MDL Number:
- MOL File:
- 802918-57-6.mol
| Melting point | 152-153°C |
|---|---|
| Boiling point | 793.0±60.0 °C(Predicted) |
| Density | 1.527±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Acetone (Sparingly, Sonicated, Heated), DMSO (Slightly), Methanol (Slightly, Heated) |
| pka | 7.39±0.60(Predicted) |
| form | Solid |
| color | Pale Yellow to Beige |
| InChIKey | SEBFKMXJBCUCAI-DBMPWETRSA-N |
| SMILES | [C@H]1(C2=CC=C3OC(CO)C(C4=CC=C(O)C(OC)=C4)OC3=C2)OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
Silybin price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89280 | Silybin (A + B mixture) phyproof? Reference Substance | 802918-57-6 | 25mg | $286 | 2024-03-01 | Buy |
| Sigma-Aldrich | 02000585 | Silybin mixture of Silybin A and B, primary reference standard | 802918-57-6 | 25mg | $845 | 2024-03-01 | Buy |
| TRC | S465850 | Silybin (A + B mixture) | 802918-57-6 | 5g | $120 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 53021 | Silybin (A + B mixture) | 802918-57-6 | 100mg | $610 | 2021-12-16 | Buy |
| AvaChem | 3619 | Silybin | 802918-57-6 | 1g | $129 | 2021-12-16 | Buy |
Silybin Chemical Properties,Uses,Production
Chemical Properties
Beige Solid
Uses
Reference standard in the analysis of herbal medicinal products.
Uses
Hepatoprotectant. In nature, the flavonolignan Silybin occurs as a mixture of two diastereomers, Silybin A and Silybin B.
General Description
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.
in vivo
Silybin (50, 100?mg/kg/day; given intragastrically for the last 4 weeks) significantly lowers both serum and hepatic lipid accumulation[2].
| Animal Model: | Male C57BL/6J mice (6-8 weeks old) with nonalcoholic fatty liver disease (NAFLD)[2] |
| Dosage: | 50, 100?mg/kg |
| Administration: | Given intragastrically; daily; for the last 4 weeks |
| Result: | Significantly lowered both serum and hepatic lipid accumulation. |
Silybin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 | 1713330907@QQ.com | China | 2639 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| PNP Biotech Co. Ltd | +8618516098983 | sales@pnpbiotech.com | China | 1001 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Hubei kangen Pharmaceutical Chemical Co., Ltd | 153-15337215803 15337215803 | 3357312443@qq.com | China | 695 | 56 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
