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CAY10654

CAY10654 Structure
CAY10654 structure
CAS No.
1298023-69-4
Chemical Name:
CAY10654
Synonyms
CAY10654;CAY10654 Exclusive;N'-(5-chloro-2-hydroxyphenyl)-N-octylpropanediamide;Propanediamide, N1-(5-chloro-2-hydroxyphenyl)-N3-octyl-
CBNumber:
CB22590455
Molecular Formula:
C17H25ClN2O3
Molecular Weight:
340.85
MDL Number:
MOL File:
1298023-69-4.mol
Last updated:2023-06-30 08:28:24
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CAY10654 Properties

Boiling point 568.5±50.0 °C(Predicted)
Density 1.186±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 20 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
form A crystalline solid
pka 7?+-.0.70(Predicted)

CAY10654 price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10857 CAY10654 ≥98% 1298023-69-4 1mg $30 2024-03-01 Buy
Cayman Chemical 10857 CAY10654 ≥98% 1298023-69-4 5mg $129 2024-03-01 Buy
Cayman Chemical 10857 CAY10654 ≥98% 1298023-69-4 10mg $225 2024-03-01 Buy
Cayman Chemical 10857 CAY10654 ≥98% 1298023-69-4 25mg $491 2024-03-01 Buy
AK Scientific 4314DK N'-(5-Chloro-2-hydroxyphenyl)-N-octylpropanediamide 1298023-69-4 1mg $131 2021-12-16 Buy
Product number Packaging Price Buy
10857 1mg $30 Buy
10857 5mg $129 Buy
10857 10mg $225 Buy
10857 25mg $491 Buy
4314DK 1mg $131 Buy

CAY10654 Chemical Properties,Uses,Production

Description

The gram-negative pathogen Pseudomonas aeruginosa uses N-acylated-L-homoserine lactones (AHLs) in quorum sensing to modulate transcriptional activators, including LasR, and regulate the expression of virulence factors. The same AHLs suppress the host immune system. CAY10654 is a synthetic analog of natural AHLs that suppresses host immunity without inducing LasR.1 It inhibits the proliferation of mouse peripheral blood leukocytes by concanavalin A (EC50 = 9.3 μM) without concurrent cytotoxicity.1 LasR is not induced by 100 μM CAY10654, although LasR is potently induced by natural AHL (5 μM) in positive control experiments.1

Definition

ChEBI: CAY10654 is an anilide.

References

1. Jadhav, G.P., Chhabra, S.R., Telford, G., et al. Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone J. Med. Chem. 54(9),3348-3359(2011).

CAY10654 synthesis

3151-49-3
95-85-2
1298023-69-4
Synthesis of CAY10654 from Propanoic acid, 3-(octylamino)-3-oxo- and 2-Amino-4-chlorophenol

CAY10654 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10654 Suppliers

Global( 19)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 28118 58
Supplier Advantage
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
CAY10654 CAY10654 Exclusive N'-(5-chloro-2-hydroxyphenyl)-N-octylpropanediamide Propanediamide, N1-(5-chloro-2-hydroxyphenyl)-N3-octyl- 1298023-69-4