Eicosapentaenoyl Serotonin
- CAS No.
- 199875-71-3
- Chemical Name:
- Eicosapentaenoyl Serotonin
- Synonyms
- Eicosapentaenoyl Serotonin;Eicosapentaenoyl Serotonin Exclusive;(5Z,8Z,11Z,14Z,17Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]icosa-5,8,11,14,17-pentaenamide;5,8,11,14,17-Eicosapentaenamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-, (5Z,8Z,11Z,14Z,17Z)-
- CBNumber:
- CB22590910
- Molecular Formula:
- C30H40N2O2
- Molecular Weight:
- 460.65
- MDL Number:
- MFCD18428062
- MOL File:
- 199875-71-3.mol
| Boiling point | 681.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.053±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
| form | solution in ethanol. |
| pka | 10.08±0.40(Predicted) |
| color | Colorless to light yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
|
Eicosapentaenoyl Serotonin price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9000640 | Eicosapentaenoyl Serotonin ≥98% | 199875-71-3 | 1mg | $66 | 2024-03-01 | Buy |
| Cayman Chemical | 9000640 | Eicosapentaenoyl Serotonin ≥98% | 199875-71-3 | 5mg | $291 | 2024-03-01 | Buy |
| Cayman Chemical | 9000640 | Eicosapentaenoyl Serotonin ≥98% | 199875-71-3 | 10mg | $516 | 2024-03-01 | Buy |
| Cayman Chemical | 9000640 | Eicosapentaenoyl Serotonin ≥98% | 199875-71-3 | 25mg | $1127 | 2024-03-01 | Buy |
| Usbiological | 448111 | Eicosapentaenoyl Serotonin | 199875-71-3 | 1mg | $368 | 2021-12-16 | Buy |
Eicosapentaenoyl Serotonin Chemical Properties,Uses,Production
Uses
Eicosapentaenoyl Serotonin is a dual fatty acid amide hydrolase and TRPV1 antagonist.
Biological Activity
eicosapentaenoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. arachidonoyl serotonin is an inhibitor of fatty acid amide hydrolase (faah) and also acts as an antagonist of transient receptor potential vanilloid-type 1 (trpv1) channels. arachidonoyl serotonin is analgesic, reducing both acute and chronic peripheral pain in rodents [1, 2]. the effects of replacement the arachidonoyl portion with eicosapentaenoic acid have not been investigated. replacement of arachidonate with saturated 11- or 12-carbon fatty acids generated compounds that potently inhibited capsaicin-induced trpv1 channel activation with an ic50 of 0.76 μm. this compound showed no effects on blocking faah-mediated hydrolysis of arachidonoyl ethanolamide with an ic50 of > 50 μm [1].
References
[1] ortar, g. ,cascio, m.g.,de petrocellis, l., et al. new n-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. journal of medicinal chemistry 50, 6554-6569 (2007).
[2] maione, s. ,de petrocellis, l.,de novellis, v., et al. analgesic actions of n-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid trpv1 receptors. british journal of pharmacology 150, 766-781 (2007).
Eicosapentaenoyl Serotonin Preparation Products And Raw materials
Raw materials
Preparation Products
Eicosapentaenoyl Serotonin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
| Supplier | Advantage |
|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
| MedBioPharmaceutical Technology Inc | 58 |
| Energy Chemical | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| ApexBio Technology | 58 |