Description
Peroxisome proliferator-activated receptors (PPARs) play an essential role in regulating lipid and glucose metabolism. Oleoyl ethanolamide (OEA), a natural ligand for PPARα, has been shown to suppress food intake and reduce weight gain in rats when administered systemically at 10 mg/kg intraperitoneally. N-Octadecyl-N''-propyl-sulfamide is an analog of OEA with selective binding affinity for PPARα. It is a more potent activator of PPARα, exhibiting an EC50 value of 100 nM, compared to OEA, which exhibits an EC50 value of 120 nM. At a dose of 1 mg/kg for 8-11 days, N-octadecyl-N''-propyl-sulfamide induces satiety, thereby decreasing food-intake, body weight, and plasma triglyceride concentration in free-feeding Wistar and obese Zucker (fa/fa) rats.
References
[1]. cano c, pavón j, serrano a, et al. novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and pparalpha activation. j med chem. 2007 jan 25;50(2):389-93.
[2]. fu j1, gaetani s, oveisi f, et al. oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor ppar-alpha. nature. 2003 sep 4;425(6953):90-3.
