N-옥타데실-N'-프로필-설파미드 C화학적 특성, 용도, 생산
개요
Peroxisome proliferator-
activated receptors (PPARs) play an essential role in regulating lipid and glucose metabolism. Oleoyl ethanolamide (OEA), a natural ligand for PPARα, has been shown to suppress food intake and reduce weight gain in rats when administered systemically at 10 mg/kg intraperitoneally. N-
Octadecyl-
N''-
propyl-
sulfamide is an analog of OEA with selective binding affinity for PPARα. It is a more potent activator of PPARα, exhibiting an EC
50 value of 100 nM, compared to OEA, which exhibits an EC
50 value of 120 nM. At a dose of 1 mg/kg for 8-
11 days, N-
octadecyl-
N''-
propyl-
sulfamide induces satiety, thereby decreasing food-
intake, body weight, and plasma triglyceride concentration in free-
feeding Wistar and obese Zucker (fa/fa) rats.
N-옥타데실-N'-프로필-설파미드 준비 용품 및 원자재
원자재
준비 용품
