ADX 10059 hydrochloride
- CAS No.
- 757949-98-7
- Chemical Name:
- ADX 10059 hydrochloride
- Synonyms
- ADX 10059 hydrochloride;2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride;3-PyridinaMine, 2-[2-(3-fluorophenyl)ethynyl]-4,6-diMethyl-, hydrochloride
- CBNumber:
- CB22596523
- Molecular Formula:
- C15H14ClFN2
- Molecular Weight:
- 276.74
- MDL Number:
- MFCD22683822
- MOL File:
- 757949-98-7.mol
ADX 10059 hydrochloride price More Price(7)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Tocris | 4416 | ADX10059hydrochloride ≥99%(HPLC) | 757949-98-7 | 10 | $189 | 2021-12-16 | Buy |
Tocris | 4416 | ADX10059hydrochloride ≥99%(HPLC) | 757949-98-7 | 50 | $762 | 2021-12-16 | Buy |
TRC | A291815 | ADX10059Hydrochloride | 757949-98-7 | 2.5mg | $250 | 2021-12-16 | Buy |
Usbiological | 254548 | ADX 10059 hydrochloride | 757949-98-7 | 10mg | $466 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | INB0001430 | ADX-10059 HYDROCHLORIDE 99.00% | 757949-98-7 | 5MG | $497 | 2021-12-16 | Buy |
ADX 10059 hydrochloride Chemical Properties,Uses,Production
Uses
ADX 10059 Hydrochloride is used in the synthetic preparation of novel 2-(hetero)arylalkynylpyridin-3-amines as mGluR5 antagonists.
Biological Activity
adx 10059 hydrochloride is a potent and selective negative allosteric modulator of mglu5 receptor with ic50 value of 17.1 nm [1].metabotropic glutamate receptor 5 (mglu5 receptor) is a g protein-coupled receptor and is a receptor for glutamate, which is a primary neurotransmitter involved in signaling in the central nervous system [2].adx 10059 hydrochloride is a potent and selective mglu5 receptor negative allosteric modulator. in patients with migraine, adx10059 caused pain-free response in 16.1% patients compared with placebo of 4.5% [1]. in patients with gastro-oesophageal reflux disease (gord) underwent 24-h oesophageal ph-metry, adx10059 (250 mg) significantly reduced the percentage of acid exposure time with ph < 4 from 7.2% to 3.6%. also, adx 10059 significantly decreased the duration and number of symptomatic reflux episodes and reduced oesophageal acid exposure [2].
storage
Room temperature
References
[1]. marin jc, goadsby pj. glutamatergic fine tuning with adx-10059: a novel therapeutic approach for migraine expert opin investig drugs, 2010, 19(4): 555-561.
[2]. keywood c, wakefield m, tack j. a proof-of-concept study evaluating the effect of adx10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease. gut, 2009, 58(9): 1192-1199.
ADX 10059 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
ADX 10059 hydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
Shanghai YuZn Pharm. Technology Co.,Ltd. | 15921286451; 15921286451 | 2010681527@qq.com | China | 5065 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4249 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |