VcMMAE
- CAS No.
- 646502-53-6
- Chemical Name:
- VcMMAE
- Synonyms
- MC-VC-PAB-MMAE;MC-Val-Cit-PAB-MMAE;VeMMAE;VcMMAE;EOS-60990;VC-MMAE;VC MMAE;MC-VC-PABC-MMAE;MC-VAL-CIT-PABC-MMAE;VcMMAE (mc-vc-PAB-MMAE);Brentuximab Impurity 1 (Vedotin)
- CBNumber:
- CB22666699
- Molecular Formula:
- C68H105N11O15
- Molecular Weight:
- 1316.63
- MDL Number:
- MFCD25372036
- MOL File:
- 646502-53-6.mol
Boiling point | 1347.6±65.0 °C(Predicted) |
---|---|
Density | 1.196±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Soluble in DMSO, DCM, DMF |
form | A solid |
pka | 13.29±0.70(Predicted) |
color | White to off-white |
InChIKey | NLMBVBUNULOTNS-NNNQBTKHNA-N |
FDA UNII | 026S2O80A8 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P280-P305+P351+P338 | |||||||||
NFPA 704 |
|
VcMMAE price More Price(18)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
BroadPharm | BP-23969 | MC-Val-Cit-PAB-MMAE 98% | 646502-53-6 | 5mg | $265 | 2021-12-16 | Buy |
BroadPharm | BP-23969 | MC-Val-Cit-PAB-MMAE 98% | 646502-53-6 | 10mg | $410 | 2021-12-16 | Buy |
BroadPharm | BP-23969 | MC-Val-Cit-PAB-MMAE 98% | 646502-53-6 | 1mg | $145 | 2021-12-16 | Buy |
ChemScene | CS-1242 | VcMMAE 99.89% | 646502-53-6 | 250mg | $1580 | 2021-12-16 | Buy |
Biorbyt Ltd | orb573074 | VcMMAE >99.11% | 646502-53-6 | 100mg | $1949.9 | 2021-12-16 | Buy |
VcMMAE Chemical Properties,Uses,Production
Description
MC-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains a thio reactive maleimidocaproyl (MC) group, a protease-sensitive Val-Cit dipeptide, a PABC linker and a MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells.
Uses
Vedotin is an ultra-high-affinity small organic ligand of fibroblast activation protein used for tumor-targeting applications
Application
VcMMAE is a MMAE derivative with valine-citrulline (Vc) linker. VcMMAE can be used to make antibody drug conjugate. VcMMAE is a anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer?
Biological Activity
VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). As a monoclonal antibody, it acts by binding to the extracellular domain of epidermal growth factor receptor (EGFR) and blocking its interaction with the ligands, thereby inhibiting cellular proliferation.
VcMMAE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
Xilinglab Co., Ltd. | +8618381337976 | bd@xilinglab.com | China | 86 | 58 |
ChemExpress | +86-021-58950125 | info@chemexpress.com | China | 599 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21671 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7353 | 58 |
TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
Jurong Coupling Biotechnology Co., Ltd. | 13656108824 | coupling278191416@hotmail.com | CHINA | 184 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29826 | 58 |
Supplier | Advantage |
---|---|
BOC Sciences | 58 |
Xilinglab Co., Ltd. | 58 |
ChemExpress | 58 |
Henan Tianfu Chemical Co.,Ltd. | 55 |
ATK CHEMICAL COMPANY LIMITED | 60 |
Biochempartner | 58 |
Jinan Carbotang Biotech Co.,Ltd. | 58 |
TopScience Biochemical | 58 |
Jurong Coupling Biotechnology Co., Ltd. | 58 |
career henan chemical co | 58 |
View Lastest Price from VcMMAE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-03-29 | MC-Val-Cit-PAB-MMAE
646502-53-6
|
US $0.00 / mg | 100mg | >98.00% | 100mg | Xian confluore Biological Technology Co., Ltd. | ||
2021-07-13 | VCMMAE
646502-53-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2020-11-25 | Fmoc-Val-Cit-PAB-MMAE
646502-53-6
|
US $1.00 / BOU/Drum | 1KG | 98% | 1kg | HONG KONG IPURE BIOLOGY CO.,LIMITED |
- MC-Val-Cit-PAB-MMAE
646502-53-6
- US $0.00 / mg
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
- VCMMAE
646502-53-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Fmoc-Val-Cit-PAB-MMAE
646502-53-6
- US $1.00 / BOU/Drum
- 98%
- HONG KONG IPURE BIOLOGY CO.,LIMITED
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