VcMMAE suppliers
VCMMAE
- CAS:
- 646502-53-6
- MF:
- C68H105N11O15
- MW:
- 1316.63
Suppliers by country/region
Company Type
Properties
- Boiling point:
- 1347.6±65.0 °C(Predicted)
- Density
- 1.196±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO, DCM, DMF
- form
- A solid
- pka
- 13.29±0.70(Predicted)
- color
- White to off-white
- InChIKey
- NLMBVBUNULOTNS-NNNQBTKHNA-N
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P280-P305+P351+P338
Use
VcMMAE is a MMAE derivative with valine-citrulline (Vc) linker. VcMMAE can be used to make antibody drug conjugate. VcMMAE is a anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer?
128 supplier list of "VCMMAE"
- Product Name:MC-Val-Cit-PAB-MMAE
- Products Intro:Purity: >98% | Package: 1mg | CustNote: BOC Sciences also provides custom synthesis services for MC-Val-Cit-PAB-MMAE.
- Company Type: Reagent
- Country/Region: UNITED STATES
- Product Name:VcMMAE
- Products Intro:Purity: 99.89% | Package: 50g;100g;1kg
- Company Type: Service provider
- Country/Region: CHINA
- Main Products: (2S,5R)-Benzyl 5-((benzyloxy)amino)piperidine-2-carboxylate oxalate,2'-Fluoro-2'-deoxyuridine,Palbociclib,Tegoprazan,Teneligliptin (hydrobromide)
- Product Name:VcMMAE
- Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:VCMMAE
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:VcMMAE
- Products Intro:Purity: 98% | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:VCMMAE
- Products Intro:Purity: 0.99 | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:VCMMAE
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Chlorogenic acid,Tea polyphenol,Acacetin,Gentiopicroside,Jatrorrhizine
- Product Name:MC-VAL-CIT-PABC-MMAE
- Products Intro:Purity: 98%+ | Package: Standard or custom package | CustNote: excellent quality and reliable supplier
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmceutical,Optical Brightening,dyes
![[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-o](https://img.chemicalbook.com/CompanyLogo/7a1d34f6-40cf-44fb-85d1-370c0cc719b320210526173348.jpg)
- Product Name:[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-o
- Products Intro:Purity: 98% | Package: 1g,10g,25g,500g,1kg | CustNote: N/A
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 528-94-9,AMMONIUM SALICYLATE,Linolenic acid,463-40-1,931-36-2