CPI-169
- CAS No.
- 1450655-76-1
- Chemical Name:
- CPI-169
- Synonyms
- CPI-169;CPI 169;CPI169;CPI-169 racemate;CPI169;CPI 169;CPI-169;CPI169 racemate,CPI 169 racemate;1-(1-(1-(Ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide;1H-Indole-3-carboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-1-[1-[1-(ethylsulfonyl)-4-piperidinyl]ethyl]-2-methyl-
- CBNumber:
- CB22715621
- Molecular Formula:
- C27H36N4O5S
- Molecular Weight:
- 528.66
- MDL Number:
- MFCD28167777
- MOL File:
- 1450655-76-1.mol
SAFETY
Risk and Safety Statements
| Signal word | Warning | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Hazard statements | H320 | |||||||||
| Precautionary statements | P264-P305+P351+P338-P337+P313 | |||||||||
| NFPA 704 |
|
CPI-169 price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18299 | CPI-169 ≥98% | 1450655-76-1 | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 18299 | CPI-169 ≥98% | 1450655-76-1 | 5mg | $235 | 2024-03-01 | Buy |
| TRC | C781428 | CPI-169 | 1450655-76-1 | 25mg | $800 | 2021-12-16 | Buy |
| ChemScene | CS-3137 | CPI-169racemate 98.52% | 1450655-76-1 | 50mg | $816 | 2021-12-16 | Buy |
| ChemScene | CS-3137 | CPI-169racemate 98.52% | 1450655-76-1 | 100mg | $1320 | 2021-12-16 | Buy |
CPI-169 Chemical Properties,Uses,Production
Uses
CPI-169 is a heteroaryl amide that was discovered useful as modulator of Me modifying enzymes.
Definition
ChEBI: 1-[1-(1-ethylsulfonyl-4-piperidinyl)ethyl]-N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-3-indolecarboxamide is an indolecarboxamide.
Biological Activity
cpi-169 is a novel, small molecule and potent inhibitor of enhancer of zeste homolog 2 (ezh2) with an ic50 value of <1nm for polycomb repressive complex 2 (prc2) [1].cpi-169 has been found to be a potent ezh2 inhibitor with an ic50 value of <1nm for polycomb repressive complex 2 (prc2). in addition, cpi-169 has been reported to reduce cellular levels of histone h3 on lysine 27(h3k27) with an ec50 value of 70nm. moreover, cpi-169 has been exhibited to trigger cell cycle arrest and apoptosis in cells. apart from these, treatment the inhibitor at 200mpk twice daily, cpi-169 has been noted to have a well tolerated in mice with no observed toxic effect or body weight loss [1].
References
[1] vidya balasubramanian, priya iyer, shilpi arora, patrick troyer, emmanuel normant. constellation pharmaceuticals, cambridge, ma. cpi-169, a novel and potent ezh2 inhibitor, synergizes with chop in vivo and achieves complete regression in lymphoma xenograft models
CPI-169 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29826 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4692 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
View Lastest Price from CPI-169 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-02 | 1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2- methyl-1H-indole-3-carboxamide
1450655-76-1
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- 1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2- methyl-1H-indole-3-carboxamide
1450655-76-1
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co