Clomethiazole
- CAS No.
- 533-45-9
- Chemical Name:
- Clomethiazole
- Synonyms
- Distraneurin;CLOMETHIAZOLE;Clomethiazolum;Chlorethiazole;chlormethiazole;ChlormethiazoleHCl;CLOMETHIAZOLE HCL;Clomethiazole in methanol;5-(2-chloroethyl)-4-methylthiazole;Thiazole, 5-(2-chloroethyl)-4-methyl-
- CBNumber:
- CB2286790
- Molecular Formula:
- C6H8ClNS
- Molecular Weight:
- 161.65
- MDL Number:
- MFCD00868012
- MOL File:
- 533-45-9.mol
| Melting point | 127-128 °C |
|---|---|
| Boiling point | bp7 92° |
| Density | d425 1.233 |
| refractive index | 1.6000 (estimate) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | pKa 3.2 (Uncertain) |
| form | Oil |
| color | Pale Yellow |
| CAS DataBase Reference | 533-45-9(CAS DataBase Reference) |
| FDA UNII | 0C5DBZ19HV |
| ATC code | N05CM02,N05CX04 |
| NIST Chemistry Reference | Clomethiazole(533-45-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H302-H319-H412 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P273-P501 |
| HS Code | 2934100090 |
Clomethiazole price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C587020 | Clomethiazolum | 533-45-9 | 2g | $450 | 2021-12-16 | Buy |
| TRC | C587020 | Clomethiazolum | 533-45-9 | 5g | $675 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0037164 | 5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE 95.00% | 533-45-9 | 5G | $1295.03 | 2021-12-16 | Buy |
| AK Scientific | X5631 | Clomethiazole | 533-45-9 | 25g | $1312 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 56059 | Clomethiazolum | 533-45-9 | 5G | $1475 | 2021-12-16 | Buy |
Clomethiazole Chemical Properties,Uses,Production
Uses
Clomethiazolum is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant.
Uses
Hypnotic.
Definition
ChEBI: 5-(2-chloroethyl)-4-methylthiazole is a member of thiazoles.
brand name
Clomiazin;Distraneurine;Emineurina;Gebriazol;Hemineurine;Heminevrin;Somnevrin.
World Health Organization (WHO)
Clomethiazole, which has sedative, anxiolytic and anticonvulsant activity, was introduced in 1960 for the treatment of acute alcohol withdrawal, delirium tremens, status epilepticus, eclamptic toxaemia, sleep disturbances in the elderly and agitation in psychogeriatic patients. It is also used as a sedative in certain anaesthetic procedures. There is little evidence of primary dependence in man but secondary dependence can occur in patients with a history of abuse of other substances, particularly alcohol. Dependence of this type has been reported as a result of inappropriate, long-term prescribing to outpatient alcoholics. Clomethiazole should not be prescribed to alcoholics who continue to drink. Adverse interactions with alcohol have been fatal. Although not controlled under the 1971 Convention on Psychotropic Substances, clomethiazole is subject to analogous controls in some countries.
Biological Activity
Sedative and anticonvulsant which is neuroprotective in a number of animal models. Prevents the degeneration of serotonergic nerve terminals induced by MDMA ('Ecstasy').
Clomethiazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21637 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2993 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32072 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15356 | 58 |
| Xi'an ZB Biotech Co.,Ltd | +8618591943808 | sales01@xazbbio.com | China | 815 | 58 |
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