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Diethyl pyrocarbonate

CAS No.
1609-47-8
Chemical Name:
Diethyl pyrocarbonate
Synonyms
DEPC;DIETHYL DICARBONATE;Ethyl pyrocarbonate;DKD;Piref;Baycovin;DEP/DEPC;DEPC/DEP;ethylpyrocarbonate;Diethylpyrokarbonat
CBNumber:
CB2300384
Molecular Formula:
C6H10O5
Molecular Weight:
162.14
MDL Number:
MFCD00009106
MOL File:
1609-47-8.mol
MSDS File:
SDS
Last updated:2024-12-18 14:07:02

Diethyl pyrocarbonate Properties

Melting point 69℃
Boiling point 93-94 °C18 mm Hg(lit.)
Density 1.12 g/mL at 20 °C
refractive index n20/D 1.398(lit.)
Flash point 157 °F
storage temp. 2-8°C
solubility 95% ethanol: soluble4.5g/10 mL, clear, colorless
form Liquid
color APHA: ≤20
Water Solubility slow decomposition
Sensitive Moisture Sensitive
Merck 14,7998
BRN 637031
Stability Combustible. Unstable - readily decomposes. Incompatible with strong oxidizing agents, strong acids, strong reducing agents, strong bases, ammonia.
InChIKey FFYPMLJYZAEMQB-UHFFFAOYSA-N
LogP 1.101 (est)
CAS DataBase Reference 1609-47-8(CAS DataBase Reference)
FDA 21 CFR 189.140
Substances Added to Food (formerly EAFUS) DIETHYL PYROCARBONATE-- PROHIBITED
EWG's Food Scores 1
FDA UNII LMR3LZG146
NIST Chemistry Reference Diethyl pyrocarbonate(1609-47-8)
EPA Substance Registry System Dicarbonic acid, diethyl ester (1609-47-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22-36/37/38-20/21/22
Safety Statements  26-36-37/39
RIDADR  2810
WGK Germany  3
RTECS  LQ9350000
4.4-9-21
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29209085
Toxicity LD50 orally in Rabbit: 850 mg/kg
NFPA 704
2
2 1

Diethyl pyrocarbonate price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.41751 Diethyl dicarbonate for synthesis 1609-47-8 5ml $35.5 2024-03-01 Buy
Sigma-Aldrich 8.41751 Diethyl dicarbonate for synthesis 1609-47-8 25mL $130 2024-03-01 Buy
Sigma-Aldrich 298711 Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. 1609-47-8 25g $159 2024-03-01 Buy
Sigma-Aldrich 3660-OP OmniPur DEPC - CAS 1609-47-8 - Calbiochem 1609-47-8 25g $269 2024-03-01 Buy
Sigma-Aldrich 298711 Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. 1609-47-8 100g $547 2024-03-01 Buy
Product number Packaging Price Buy
8.41751 5ml $35.5 Buy
8.41751 25mL $130 Buy
298711 25g $159 Buy
3660-OP 25g $269 Buy
298711 100g $547 Buy

Diethyl pyrocarbonate Chemical Properties,Uses,Production

Chemical Properties

liquid

Uses

Modification reagent for His and Tyr residues in proteins. Robust probe for structural disruptions in dsDNA, reacting with fully or partially unstacked bases.1

Uses

Diethyl pyrocarbonate may be used in the following studies:

  • For the modification of histidyl residues in proteins.
  • As a nuclease inhibitor, for the extraction of undegraded nucleic acids from etiolated and green plant tissues.
  • For the modification of linear and supercoiled plasmid DNAs.
  • As a chemical probe to investigate the secondary structure in negatively supercoiled DNA.
  • For cabethoxylation of histidine residues of actin.

Uses

Gentle esterifying agent. Preservative for wines, soft drinks, fruit juices.

Definition

ChEBI: The diethyl ester of dicarbonic acid.

General Description

Diethyl pyrocarbonate (DEP) is a bactericidal agent and decomposes in water to CO2 and ethanol. DEP inhibits enzymes such as DNase and RNase without affecting nucleic acids. It is useful for the preparation of mRNA from tissues.

Biochem/physiol Actions

Inactivates RNase in solution at about 0.1% (v/v), thus protecting RNA against degradation.

Safety Profile

Poison by ingestion, inhalation, and intraperitoneal routes. Concentrated DEPC is irritating to eyes, mucous membranes, and sh. When heated to decomposition it emits acrid smoke and fumes. See also ESTERS.

Purification Methods

Dissolve the ester in Et2O, wash it with dilute HCl, H2O, dry over Na2SO4, filter, evaporate and distil the residue first in vacuo then at atmospheric pressure. It is soluble in alcohols, esters, ketones and hydrocarbon solvents. A 50% w/w solution is usually prepared for general use. Treat with great CAUTION as DEP irritates the eyes, mucous membranes and skin. [Boehm & Mehta Chem Ber 71 1797 1938, Thoma & Rinke Justus Liebigs Ann Chem 624 30 1959, Beilstein 3 IV 18.]

541-41-3
124-30-1
1609-47-8
Synthesis of Diethyl pyrocarbonate from Ethyl chloroformate and Octadecanamine

Diethyl pyrocarbonate Preparation Products And Raw materials

Global( 388)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Weibang Biotechnology Co., Ltd
+8615531157085 abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12834 58
Hebei Kingfiner Technology Development Co.Ltd
+86-15532196582 +86-15373005021 lisa@kingfinertech.com China 3010 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806 sales@capot.com China 29791 60
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+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co
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Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
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86-13657291602 linda@hubeijusheng.com CHINA 22963 58
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18853181302 sale@chuangyingchem.com CHINA 5906 58

View Lastest Price from Diethyl pyrocarbonate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DEPC pictures 2024-11-19 DEPC
1609-47-8
US $68.00 / mg 99.58% 10g TargetMol Chemicals Inc.
Diethyl pyrocarbonate pictures 2024-11-18 Diethyl pyrocarbonate
1609-47-8
US $1.00 / KG 1KG 99% 10 mt Hebei Weibang Biotechnology Co., Ltd
Diethyl pyrocarbonate pictures 2024-06-11 Diethyl pyrocarbonate
1609-47-8
US $0.00-0.00 / kg 1kg 99% 50000kg Hebei Kingfiner Technology Development Co.Ltd
  • DEPC pictures
  • DEPC
    1609-47-8
  • US $68.00 / mg
  • 99.58%
  • TargetMol Chemicals Inc.
Diethyl dicarbonate for synthesis DEPC, diethypyrocarbonate Diethyl pyrocarbonate Vetec(TM) reagent grade, >=97% diethylesterofpyrocarbonicacid diethylpyrocarbonicacid Diethylpyrokarbonat DKD ethylpyrocarbonate Formic acid, oxydi-, diethyl ester oxydi-formicacidiethylester Piref Pyrocarbonate d'ethyle pyrocarbonated’ethyle Pyrokohlensaeure diaethyl ester DiethylPyrocarbonate(Depc) Oxdiformic acid, diethyl ester Diethyl pyrocarbonate, pure, 97% DIETHYL PYROCARBONATE DIETHYL OXYDIFORMATE ETHOXYFORMIC ACID ANHYDRIDE ETHOXYFORMIC ANHYDRIDE Diethyl Pyrocarbonate (DEPC)(strong product) DIETHYL PYROCARBONATE extrapure DEP, DEPC, Diethyl dicarbonate, Diethyl oxydiformate, Ethoxyformic acid anhydride DEPC(Diethepyrocarbonate) Diethyl pyrocarbonate ,97% Diethyl pyrocarbonate research grade Diethyl pyrocarbonate,DEP, DEPC, Diethyl dicarbonate, Diethyl oxydiformate, Ethoxyformic acid anhydride Diethyl pyrocarbonat OXYDIFORMIC ACID DIETHYL ESTER PYROCARBONIC ACID DIETHYL ESTER Baycovin Dicarbonic acid, diethyl ester dicarbonicacid,diethylester dicarbonicaciddiethylester Diethyl ester of pyrocarbonic acid Diethyl pyrocarbonic acid Diethylester kyseliny diuhlicite diethylesterkyselinydiuhlicite Diethyl pyrocarbonate, pure, 97% 25GR Diethyl pyrocarbonate, pure, 97% 5GR Diethyl pyrocarbonate, 97%, pure Pyrocarbonic acid diethyl DEPC (Diethyl pyrocarbonate) Cokecarbonic acidethyl ester two Diethyl pyrocarbonate 99% (NT) Diethyl dicarbonate Diethyl oxydiformate Ethoxyformic acid anhydride Pyrocarbonic acid diethyl ester Diethyl pyrocarbonate, 97%, for bio Dicarbonic acid, 1,3-diethyl ester iethylpyrocarbonate DEP/DEPC Factory supply high quality Diethyl pyrocarbonate CAS 1609-47-8 with good price ethoxycarbonyl ethyl carbonate Diethyl Pyrocarbonate (DEPC) for molecular biology, 99% OmniPur DEPC - CAS 1609-47-8 - Calbiochem Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem Ethyl pyrocarbonate DIETHYL DICARBONATE