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Diethyl phosphite

Diethyl phosphite structure

CAS No.: 762-04-9

Chemical Name:: Diethyl phosphite

Synonyms: DIETHYL PHOSPHONATE;PHOSPHONIC ACID DIETHYL ESTER;1-ethoxyphosphonoyloxyethane;DIETHYL HYDROGEN PHOSPHITE;diethylacidphosphite;Diethyl phosphite,98%;OPH(OC2H5)2;diethylfosfit;AURORA KA-1208;Diethyl phosphit

CBNumber:: CB7318904

Molecular Formula:: C4H11O3P

Molecular Weight:: 138.1

MDL Number:: MFCD00044573

MOL File:: 762-04-9.mol

Last updated:2025-02-13 18:31:58

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Diethyl phosphite Properties

Melting point	-70 °C
Boiling point	50-51 °C/2 mmHg (lit.)
Density	1.072 g/mL at 25 °C (lit.)
vapor pressure	7hPa at 20℃
refractive index	n20/D 1.407(lit.)
Flash point	180 °F
form	Liquid
color	Colorless
Specific Gravity	1.072
Water Solubility	miscible (hydrolysis)
Sensitive	Moisture Sensitive
Hydrolytic Sensitivity	7: reacts slowly with moisture/water
BRN	605759
Stability	Stable. Incompatible with strong oxidizing agents, strong acids, acid chlorides, strong bases. May decompose on exposure to moisture. Combustible.
InChIKey	MJUJXFBTEFXVKU-UHFFFAOYSA-N
LogP	-0.15
CAS DataBase Reference	762-04-9(CAS DataBase Reference)
FDA UNII	U9X9YBA22W
NIST Chemistry Reference	Phosphonic acid, diethyl ester(762-04-9)
EPA Substance Registry System	Diethyl phosphite (762-04-9)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H317-H318

Precautionary statements

P261-P272-P280-P302+P352-P305+P351+P338-P333+P313

Hazard Codes

Risk Statements

36/37/38-43

Safety Statements

26-36/37/39-37/39-28-27

WGK Germany

RTECS

TG7875000

10-13-21

TSCA

Yes

HS Code

29209014

Hazardous Substances Data

762-04-9(Hazardous Substances Data)

NFPA 704

	2
2		0

Diethyl phosphite price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D99234	Diethyl phosphite 98%	762-04-9	250g	$69.7	2024-03-01	Buy
Sigma-Aldrich	365920	Diethyl phosphite technical grade, 94%	762-04-9	1l	$149	2024-03-01	Buy
Alfa Aesar	043801	Diethyl phosphite, 96%	762-04-9	250g	$71.5	2023-06-20	Buy
Alfa Aesar	043801	Diethyl phosphite, 96%	762-04-9	1kg	$223	2023-06-20	Buy
Strem Chemicals	93-1521	Diethylphosphite, min. 95%	762-04-9	100g	$49	2024-03-01	Buy

Product number	Packaging	Price	Buy
D99234	250g	$69.7	Buy
365920	1l	$149	Buy
043801	250g	$71.5	Buy
043801	1kg	$223	Buy
93-1521	100g	$49	Buy

Diethyl phosphite Chemical Properties,Uses,Production

Chemical Properties

colourless liquid

Uses

Diethyl phosphite is precursor used for the synthesis of various organophosphorus compounds. used to prepare the nickel chloride-diethyl phosphite system, efficient catalyst for the cross-coupling reaction between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides.

Uses

Diethyl phosphite (DEPI) is a versatile reactive intermediate used in the production of various phosphorus based substances. It may be used to prepare the nickel chloride-diethyl phosphite system, efficient catalyst for the cross-coupling reaction between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides.
It may be used:

in the stereoselective synthesis of β-fluorinated alkylphosphonates
Used in synthesis of homoallylic bromide
Used in synthesis of series of carbazole-based α-aminophosphonates
used as an extraction agent and phosphate intermediate.
Used in synthesis of pesticides kitazine and phosethyl-Al as well as synthetic O, O-diethyl phosphoryl chloride.
used for the synthesis of plasticizers, flame retardants, etc.
Diethyl phosphite is reported to be chemical warfare agent (CWA) simulant, simulant for nerve agents sarin, soman, tabun, and VX.

Definition

ChEBI: A phosphonic ester that is the diethyl ester of phosphonic acid.

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 3327, 1988 DOI: 10.1016/0040-4039(88)85153-0

Synthesis Reference(s)

Synthetic Communications, 18, p. 665, 1988 DOI: 10.1080/00397918808077352

General Description

Diethyl phosphite is reported to be chemical warfare agent (CWA) simulant, simulant for nerve agents sarin, soman, tabun, and VX.

Diethyl phosphite Preparation Products And Raw materials

Raw materials

Stirring vessel Nitrogen Oil pump Water pump

Preparation Products

(S)-(-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL SODIUM O,O-DIETHYLTHIOPHOSPHATE Diphenylphosphine oxide Phosphite Optical brightener OB-1

FOSAMINE AMMONIUM (S)-(-)-7,7'-BIS[DI(3,5-DIMETHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE PARAOXON Diethyl chlorophosphate (S)-7,7'-Bis[di(p-methylphenyl)phosphino]-1,1'-spirobiindane ,97%

Diethyl 3,5-di-tert-butyl-4-hydroxybenzyl phosphate (R)-(+)-7,7'-BIS[DI(4-METHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE 4,4'-Vinylenedipyridine Iprobenfos Ethephon

(R)-(+)-7,7'-BIS(DIPHENYLPHOSPHINO)-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE Foscarnet sodium Fosetyl aluminum DIETHYL PHOSPHATE (R)-(+)-TolBINAP

ETHYLPHOSPHONIC ACID (R)-7,7'-BIS(DIPHENYLPHOSPHINO)-1,1'-SPIROBIINDANE Triethyl phosphite

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Diethyl phosphite Suppliers

Global( 397)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangsu Nengyue New Material Technology Co.,Ltd	+undefined+86-13376001577	robinlu.jian@foxmail.com	China	31	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531157085	abby@chuanghaibio.com	China	8808	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12806	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5868	58
ShenZhen H&D Pharmaceutical Technology Co., LTD	+8618627948422	sale@hdimpurity.com	China	3619	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21628	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29858	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10406	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88299272	info@edengenechem.com	China	2176	58

Supplier	Advantage
Jiangsu Nengyue New Material Technology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
ShenZhen H&D Pharmaceutical Technology Co., LTD	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
Changzhou Ditong Chemical Co.,Ltd	58

View Lastest Price from Diethyl phosphite manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-23	Diethyl phosphite 762-04-9	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-03-21	Diethyl phosphite 762-04-9	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mujin Biotechnology Co.,Ltd
2025-03-04	Tenofovir impurity 82	US $0.00 / mg	10mg	0.98	5g	ShenZhen H&D Pharmaceutical Technology Co., LTD

Diethyl phosphite
762-04-9
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

Diethyl phosphite
762-04-9
US $0.00 / KG
99%
Hebei Mujin Biotechnology Co.,Ltd

Tenofovir impurity 82
US $0.00 / mg
0.98
ShenZhen H&D Pharmaceutical Technology Co., LTD

Diethyl phosphite Spectrum

Diethyl phosphite(762-04-9)MS Diethyl phosphite(762-04-9)¹HNMR Diethyl phosphite(762-04-9)¹³CNMR Diethyl phosphite(762-04-9)IR1 Diethyl phosphite(762-04-9)IR2 Diethyl phosphite(762-04-9)Raman

762-04-9(Diethyl phosphite)Related Search:

Diethyl malonate Hydrogen Diethylphosphorodithioate Triphenyl phosphite Diethyl carbonate

Diethyl phthalate Orthophosphorus acid Mefenpyr-diethyl DIETHYL ETHYLPHOSPHONATE Triethyl phosphite

Diethyl cyanomethylphosphonate DIETHYL PHOSPHATE Diethyl cyanophosphonate Dibenzyl phosphite Diisopropyl phosphite

Dimethyl phosphite Tenofovir Impurity 89 Tenofovir Disoproxil Isopropoxycarbonyl

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diethylfosfit Ethyl phosphonate ((EtO)2HPO) Phosphorous acid diethyl Phosphorous acid hydrogen diethyl Phosphonic acid diethyl Phosphonic Acid Diethyl Ester Diethyl Phosphonate Phosphorous Acid Diethyl Ester Diethyl phosphit Phosphorous acidethyl ester two Diethylphosphite, min. 95% Diethyl phosphite technical grade Diethoxyphosphine oxide Diethyl acid phosphite Hydrogen diethyl phosphite hydrogendiethylphosphite O,O-Diethyl phosphonate OPH(OC2H5)2 PHOSPHOROUS ACID DIETHYL ESTER Diethyl hydrogen phosphonate DIETHYL PHOSPHITE AURORA KA-1208 Diethylphosphitemincolorlessliq DIETHYL PHOSPHITE, TECH., 94% O,O"-DIETHYL PHOSPHITE Diethylphosphite,min.95% Phosphonsurediethylester Diethyl phosphite, 97+% Diethyl phosphite, 95+% Tenofovir Impurity 82 Diethylphosphonat Diethyl phosphite（DEP） diethylacidphosphite PHOSPHONIC ACID DIETHYL ESTER DIETHYL HYDROGEN PHOSPHITE DIETHYL PHOSPHONATE 1-ethoxyphosphonoyloxyethane Diethyl phosphite,98% diphenyl bis((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)diphosphonate 762-04-9 15647-08-2(762-04-9) C4H11O3P C2H52PO3 C4H11O3P4 C2H5O2POH C2H5O2PHO Phosphorus Precursors Organic Phosphates/Phosphites Phosphorus Compounds Organic Building Blocks Catalysis and Inorganic Chemistry Building Blocks Organic Building Blocks Organic Phosphates/Phosphites Catalysis and Inorganic Chemistry Phosphorus Compounds Phosphorus Precursors organophosphorus compound Building Blocks Chemical Synthesis