Verbascoside
- CAS No.
- 61276-17-3
- Chemical Name:
- Verbascoside
- Synonyms
- ACTEOSIDE;ISOVERBASCOSIDE;Acetoside;KUSAGININ;Kusagi;TJC 160;NSC 603831;Russetinol;Verbacoside;VERBASCOSIDE
- CBNumber:
- CB2306760
- Molecular Formula:
- C29H36O15
- Molecular Weight:
- 624.59
- MDL Number:
- MFCD00221751
- MOL File:
- 61276-17-3.mol
Melting point | 232℃ |
---|---|
Boiling point | 908.8±65.0 °C(Predicted) |
Density | 1.60±0.1 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Ethyl Acetate (Very Slightly), Methanol (Slightly) |
pka | 9.31±0.10(Predicted) |
form | Solid |
color | White to Pale Yellow |
Stability | Hygroscopic |
InChIKey | FBSKJMQYURKNSU-ZLSOWSIRSA-N |
LogP | 0.077 (est) |
CAS DataBase Reference | 61276-17-3(CAS DataBase Reference) |
FDA UNII | 3TGX09BD5B |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Safety Statements | 24/25 |
WGK Germany | 2 |
RTECS | LZ5786000 |
HS Code | 29389090 |
Toxicity | LD50 oral in rat: > 5gm/kg |
Verbascoside price More Price(52)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 1711455 | Verbascoside United States Pharmacopeia (USP) Reference Standard | 61276-17-3 | 15mg | $539 | 2024-03-01 | Buy |
Sigma-Aldrich | 00820580 | Verbascoside primary pharmaceutical reference standard | 61276-17-3 | 10mg | $570 | 2024-03-01 | Buy |
Sigma-Aldrich | PHL89289 | Verbascoside phyproof? Reference Substance | 61276-17-3 | 10MG | $435 | 2023-01-07 | Buy |
TCI Chemical | V0153 | Verbascoside >97.0%(HPLC) | 61276-17-3 | 10mg | $141 | 2024-03-01 | Buy |
TCI Chemical | V0153 | Verbascoside >97.0%(HPLC) | 61276-17-3 | 50mg | $494 | 2024-03-01 | Buy |
Verbascoside Chemical Properties,Uses,Production
Description
Verbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity.
Natural occurrences
Verbascoside can be found in species in all the families of the order Lamiales (syn. Scrophulariales). Only two examples are known from outside the order,in the clade Asterids.
Mechanism of action
It is known, that amyloid fibrils accumulation in cerebral can easily lead to neurodegenerative disorders. Acteoside has been reported to inhibit Aβ42 aggregation by activating nuclear translocation of the transcription factor NF-E2-related factor 2 (Nrf2), increasing heme oxygenase-1 (HO-1) expression. It has also been shown that acteoside could decrease nitric oxide synthase (NOS) activity and caspase-3 expression.
Chemical Properties
White solid
Uses
Verbascoside is an agent producing effects on anti-GBM nephritis in rats. Effective agent against glomerulonephritis. Phenolic anti-oxidant agent.
Definition
ChEBI: Acteoside is a glycoside that is the alpha-L-rhamnosyl-(1->3)-beta-D-glucoside of hydroxytyrosol in which the hydroxy group at position 4 of the glucopyranosyl moiety has undergone esterification by formal condensation with trans-caffeic acid. It has a role as a neuroprotective agent, an antileishmanial agent, an anti-inflammatory agent, a plant metabolite and an antibacterial agent. It is a cinnamate ester, a disaccharide derivative, a member of catechols, a polyphenol and a glycoside. It is functionally related to a hydroxytyrosol and a trans-caffeic acid.
Enzyme inhibitor
This plant glycoside and antioxidant (FW = 624.60 g/mol; CAS 61276-173), also known as verbascoside, inhibits TNFa-mediated apoptosis in LPSstimulated macrophages as well as 1-methyl-4-phenylpyridiniuminduced apoptosis in cerebellar granule neurons. It also inhibits proliferation of human promyelocytic HL-60 leukemia cells by inducing cell cycle arrest at the G0/G1 phase, followed by differentiation into monocytes. Acteoside inhibits PMA-induced invasion and migration of human fibrosarcoma cells by Ca2+-dependent CaMK/ERK and JNK/NFκB-signaling pathways. Acteoside thus shows the potential as antimetastatic agent. Another intriguing finding is that acteoside inhibits amyloid-β aggregation. Target(s): aldose reductase; protein kinase C; integrase, HIV-1; peptidyl-dipeptidase A, or angiotensin-converting enzyme; tyrosinase, or monophenol monooxygenase; 5-lipoxygenase, or arachidonate 5-lipoxygenase.
Verbascoside Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21663 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9284 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
View Lastest Price from Verbascoside manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-30 | Desertliving Cistanche Extract
61276-17-3
|
US $0.00 / Kg/Bag | 2Kg/Bag | Echinacoside 80% | 20 tons | Sinoway Industrial co., ltd. | ||
2024-09-30 | Desertliving Cistanche Extract
61276-17-3
|
US $0.00 / Kg/Bag | 2Kg/Bag | Echinacoside 80% | 20 tons | Sinoway Industrial co., ltd. | ||
2024-09-30 | Cistanche Deserticola Extract Acteoside; Verbascoside; Kusaginin
61276-17-3
|
US $0.00-0.00 / kg | 1kg | 1-98% | 1000kg | Changsha Staherb Natural Ingredients Co., Ltd. |
- Desertliving Cistanche Extract
61276-17-3
- US $0.00 / Kg/Bag
- Echinacoside 80%
- Sinoway Industrial co., ltd.
- Desertliving Cistanche Extract
61276-17-3
- US $0.00 / Kg/Bag
- Echinacoside 80%
- Sinoway Industrial co., ltd.
- Cistanche Deserticola Extract Acteoside; Verbascoside; Kusaginin
61276-17-3
- US $0.00-0.00 / kg
- 1-98%
- Changsha Staherb Natural Ingredients Co., Ltd.