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(S)-tert-butyl (2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate

(S)-tert-butyl (2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate structure

CAS No.: 1448440-50-3

Chemical Name:: (S)-tert-butyl (2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate

Synonyms: 133998;(S)-1-[2-(Boc-amino)acetyl]-4,4-difluoropyrrolidine-2-carbonitrile;(S)-tert-butyl (2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate;tert-butyl (S)-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate;1,1-Dimethylethyl N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]carbamate;Carbamic acid, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-, 1,1-dimethylethyl ester

CBNumber:: CB23150836

Molecular Formula:: C12H17F2N3O3

Molecular Weight:: 289.28

MDL Number:: MFCD29049850

MOL File:: 1448440-50-3.mol

Last updated:2023-07-14 17:29:38

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(S)-tert-butyl (2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate Properties

Boiling point	465.4±45.0 °C(Predicted)
Density	1.26±0.1 g/cm3(Predicted)
pka	11.55±0.46(Predicted)

(S)-tert-butyl (2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	153692	(S)-tert-Butyl (2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate 95%	1448440-50-3	10mg	$556	2021-12-16	Buy
Matrix Scientific	153692	(S)-tert-Butyl (2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate 95%	1448440-50-3	25mg	$926	2021-12-16	Buy
AK Scientific	2080EB	(S)-Tert-butyl(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate	1448440-50-3	1g	$1545	2021-12-16	Buy

Product number	Packaging	Price	Buy
153692	10mg	$556	Buy
153692	25mg	$926	Buy
2080EB	1g	$1545	Buy

(S)-tert-butyl (2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate Chemical Properties,Uses,Production

Uses

(S)-tert-Butyl (2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate is an intermediate in the synthesis of (S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide (UAMC1110) (S687910) which is a useful research chemical and a fibroblast activation protein inhibitor displaying low nanomolar inhibitory potency and high selectivity against related dipeptidyl peptidases.

(S)-tert-butyl (2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate synthesis

Synthesis of (S)-tert-butyl (2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate from BOC-Glycine and (S)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride

(S)-tert-butyl (2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide (S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile 2,2,2-trifluoroacetate (S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile 4-methylbenzenesulfonate

(S)-tert-butyl (2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate Suppliers

Global( 23)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	19825	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	sales@accelachem.com	China	11616	64
ChemShuttle, Inc.	0150-83588313-811 18800520310	sales@chemshuttle.com	China	2999	62
Mashilabs (Shanghai) Co.,Ltd.	19916721580	mafarm@126.com	China	4291	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4601	55
ShangHai Angti Biotechnology Co., Ltd.	13764913901	info@angtibio.com	China	5077	55
BioPharmaMatrix,Inc.	0510-86010668	sales@biopharmamatrix.com	China	4641	55
Zhengzhou Huiju Chemical Co., Ltd.	0371-0371-55900031 18137872243	2853979815@qq.com	China	10112	55
Wuxi KaideRui Pharmaceutical Technology Co., Ltd	19906241957	1557216087@qq.com	China	1781	55

Supplier	Advantage
Accela ChemBio Inc.	58
Amadis Chemical Company Limited	58
Accela ChemBio Co.,Ltd.	64
ChemShuttle, Inc.	62
Mashilabs (Shanghai) Co.,Ltd.	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
ShangHai Angti Biotechnology Co., Ltd.	55
BioPharmaMatrix,Inc.	55
Zhengzhou Huiju Chemical Co., Ltd.	55
Wuxi KaideRui Pharmaceutical Technology Co., Ltd	55

(S)-tert-butyl (2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate 133998 (S)-1-[2-(Boc-amino)acetyl]-4,4-difluoropyrrolidine-2-carbonitrile Carbamic acid, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-, 1,1-dimethylethyl ester tert-butyl (S)-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate 1,1-Dimethylethyl N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]carbamate 1448440-50-3 C12H17F2N3O3