ChemicalBook >> CAS DataBase List >>AEM1
AEM1
- CAS No.
- 1030123-90-0
- Chemical Name:
- AEM1
- Synonyms
- AEM1 >=98% (HPLC);AEM1, 10 mM in DMSO;AEM1 (NRF2 inhibitor AEM1);AEM-1,AEM1,inhibit,AEM 1,Inhibitor,Keap1-Nrf2;N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;Thieno[2,3-d]pyrimidin-4-amine, N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-;N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;N-[(2H-1,3-benzodioxol-5-yl)methyl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;1-(2H-1,3-benzodioxol-5-yl)-N-[5-(4-fluorophenyl)-1H,4H-thieno[2,3-d]pyrimidin-4-ylidene]methanamine
- CBNumber:
- CB23152537
- Molecular Formula:
- C20H14FN3O2S
- Molecular Weight:
- 379.41
- MDL Number:
- MFCD15017488
- MOL File:
- 1030123-90-0.mol
Last updated:2025-01-27 09:38:02
| Boiling point | 582.1±50.0 °C(Predicted) |
|---|---|
| Density | 1.457±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL; DMSO: 20 mg/mL; Ethanol: 0.25 mg/mL |
| form | A crystalline solid |
| pka | 5.04±0.40(Predicted) |
| color | White to off-white |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
AEM1 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18321 | AEM1 ≥98% | 1030123-90-0 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18321 | AEM1 ≥98% | 1030123-90-0 | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 18321 | AEM1 ≥98% | 1030123-90-0 | 500μg | $35 | 2021-12-16 | Buy |
| Cayman Chemical | 18321 | AEM1 ≥98% | 1030123-90-0 | 5mg | $100 | 2024-03-01 | Buy |
| TRC | B206920 | N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine | 1030123-90-0 | 500g | $50 | 2021-12-16 | Buy |
AEM1 Chemical Properties,Uses,Production
Uses
N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine Inhibits deregulated NRF2 transcriptional activity in cancer.
Biological Activity
AEM1 (ARE expression modulator 1) is also a selective inhibitor of sirtuin 2, which is a protein deacetylase mediated by NAD+. Sirtuin 2 supports tumor cell proliferation, thus its inhibition stimulates cell death in tumors.', 'AEM1 is a potent inhibitor of deregulated Nrf2 transcriptional activity. AEM1 broadly decreases the expression of NRF2 controlled genes and sensitizes A549 cells to various chemotherapeutic agents.
AEM1 Preparation Products And Raw materials
Raw materials
Preparation Products
AEM1 Suppliers
Global( 46)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30236 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4571 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
AEM1
(NRF2 inhibitor AEM1)
Thieno[2,3-d]pyrimidin-4-amine, N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-
AEM1 >=98% (HPLC)
AEM-1,AEM1,inhibit,AEM 1,Inhibitor,Keap1-Nrf2
1-(2H-1,3-benzodioxol-5-yl)-N-[5-(4-fluorophenyl)-1H,4H-thieno[2,3-d]pyrimidin-4-ylidene]methanamine
N-[(2H-1,3-benzodioxol-5-yl)methyl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
AEM1, 10 mM in DMSO
1030123-90-0