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CAY10677

CAY10677 Structure
CAY10677 structure
CAS No.
1443253-20-0
Chemical Name:
CAY10677
Synonyms
CAY10677;5-[3-(diethylaminomethyl)-1-octylindol-5-yl]pyrimidin-2-amine;1H-Indole-3-methanamine, 5-(2-amino-5-pyrimidinyl)-N,N-diethyl-1-octyl-
CBNumber:
CB23152577
Molecular Formula:
C25H37N5
Molecular Weight:
407.59
MDL Number:
MOL File:
1443253-20-0.mol
Last updated:2023-05-21 10:59:17
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CAY10677 Properties

storage temp. Store at -20°C
solubility DMF: 16 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml
form A crystalline solid

CAY10677 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 14744 CAY10677 ≥98% 1443253-20-0 1mg $54 2024-03-01 Buy
Cayman Chemical 14744 CAY10677 ≥98% 1443253-20-0 5mg $207 2024-03-01 Buy
Cayman Chemical 14744 CAY10677 ≥98% 1443253-20-0 10mg $333 2024-03-01 Buy
AK Scientific 0868DV 5-[3-(Diethylaminomethyl)-1-octylindol-5-yl]pyrimidin-2-amine 1443253-20-0 5mg $326 2021-12-16 Buy
Product number Packaging Price Buy
14744 1mg $54 Buy
14744 5mg $207 Buy
14744 10mg $333 Buy
0868DV 5mg $326 Buy

CAY10677 Chemical Properties,Uses,Production

Description

Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis. Isoprenylcysteine carboxyl methyltransferase (Icmt) catalyzes the methylation of C-terminal prenylcysteine residues, the last step in this process. CAY10677 is an analog of the Icmt inhibitor cysmethynil that was developed for improved solubility and cell permeability.1 CAY10677 inhibits Icmt with an IC50 value of 0.86 μM and demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells (IC50s = 2.63 versus 27.4 μM, respectively) and human prostate cancer PC3 cells (IC50s = 2.55 versus 25.2 μM, respectively).1

References

1. Ramanujulu, P.M., Yang, T., Yap, S.Q., et al. Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt) Eur. J. Med. Chem. 63,378-386(2013).

CAY10677 Preparation Products And Raw materials

Raw materials

5-Bromoindole

Preparation Products

CAY10677 Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24647 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 5597 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11975 58
Supplier Advantage
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
CAY10677 5-[3-(diethylaminomethyl)-1-octylindol-5-yl]pyrimidin-2-amine 1H-Indole-3-methanamine, 5-(2-amino-5-pyrimidinyl)-N,N-diethyl-1-octyl- 1443253-20-0 C25H37N5