Troxerutin
- CAS No.
- 7085-55-4
- Chemical Name:
- Troxerutin
- Synonyms
- Troxerutine;Venoruton;Troxerutin CRS;RUVEN;95%UV;Z-6000;95% UV;Qucrutin;Rufen P-4;VASTRIBIL
- CBNumber:
- CB2317568
- Molecular Formula:
- C33H42O19
- Molecular Weight:
- 742.68
- MDL Number:
- MFCD00893813
- MOL File:
- 7085-55-4.mol
- MSDS File:
- SDS
Melting point | 181°C |
---|---|
Boiling point | 1058.4±65.0 °C(Predicted) |
Density | 1.65±0.1 g/cm3(Predicted) |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | Freely soluble in water, slightly soluble in ethanol (96 per cent) and practically insoluble in methylene chloride. |
form | Solid |
pka | 5.92±0.40(Predicted) |
color | Light Yellow to Yellow |
Merck | 14,9789 |
BRN | 4778232 |
InChIKey | KMPBUGGPUQOWMJ-NXPSPVSKSA-N |
CAS DataBase Reference | 7085-55-4(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 7Y4N11PXO8 |
ATC code | C05CA04,C05CA54 |
UNSPSC Code | 12352200 |
NACRES | NA.21 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P264-P270-P301+P312-P330-P501 |
Safety Statements | 22-24/25 |
WGK Germany | 3 |
RTECS | LK8331500 |
HS Code | 2938100000 |
Troxerutin price More Price(40)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | Y0000497 | Troxerutin European Pharmacopoeia (EP) Reference Standard | 7085-55-4 | y0000497 | $220 | 2024-03-01 | Buy |
Sigma-Aldrich | PHR2815 | Troxerutin certified reference material, pharmaceutical secondary standard | 7085-55-4 | 50MG | $365 | 2024-03-01 | Buy |
TCI Chemical | T3541 | Troxerutin >90.0%(HPLC) | 7085-55-4 | 5g | $52 | 2024-03-01 | Buy |
TCI Chemical | T3541 | Troxerutin >90.0%(HPLC) | 7085-55-4 | 25g | $154 | 2024-03-01 | Buy |
Cayman Chemical | 27220 | Troxerutin | 7085-55-4 | 10g | $55 | 2024-03-01 | Buy |
Troxerutin Chemical Properties,Uses,Production
Chemical Properties
Yellow Powder
Originator
Venoruton,Novartis Co
Uses
vasoprotectant
Uses
Used in the treatment of venous disorders
Uses
Troxerutin, a derivative of the naturally occurring bioflavonoid rutin, is thought to inhibit red cell and platelet aggregation, improve erythrocyte deformability, and improve plasma viscosity retinal microcirculation. A double-blind randomized clinical trial compared troxerutin with placebo in 27 patients with CRVO. The limitations of the study included a small number of patients and short follow-up time.
Manufacturing Process
In a nitrogen atmosphere 120 g of caustic soda (3 moles) in solution are added to 610 g of rutin (1 mol) suspended in 2 litres of water, the mixture being vigorously agitated by a mechanical stirrer, 241.5 g of ethylene chlorohydrin being then introduced at 55°C for 10 min. When all the chlorohydrin has been thus added the temperature is progressively raised to 75°C and maintained at this level for 2 hours. After cooling, in a nitrogen atmosphere, the pH value adjusted to 5 by the addition of dilute hydrochloric acid. The solution is kept in an ice box for 24 hours and then filtered to remove any impurities. At reduced pressure the solution is evaporated until dry, the residue taken up in 3 litres of boning methanol which dissolves the tri-(β-hydroxyethyl)rutin formed and leaves the sparingly soluble sodium chloride behind. The tri-(β-hydroxyethyl)rutin is recovered from its methanolic solution either by evaporation and refrigeration, or by evaporation precipitation with absolute ethanol. In either case tri-(β-hydroxyethyl)rutin obtained is in the form of small very hygroscopic crystals which contain alcohol of crystallization.These crystals are quickly shaken washed in a little cold absolute ethanol and then dried in vacuum at 100°C. 680 g of anhydrous tri-(β-hydroxyethyl)rutin are thus obtained in the form of a yellow powder which melts at 156°C.GB Patent No. 833,174; April 21, 1960; Assigned to Zyma S.A., a Swiss Corporation, of Route Etraz, Nyon Canton of Vaud, Switzerland
Therapeutic Function
Topical venotonic
Biological Activity
Troxerutin is a brain penetrant, vasoprotective flavonol isolated from Sophora japonica, which is present in many other plants including grains, fruits, and vegetables. Troxerutin exhibits multiple biological activities including anti-oxidative, anti-radiation, and anti-inflammatory. Recent study indicates th at troxerutin improves the synaptic failure induced by Aβ peptide. It appears th at Troxerutin could promote radioprotection by stimulating NEAT1 to upregulate PDPK1 expression by suppressing miR-147.
target
VEGFR | Wnt/β-catenin | NF-kB | SOD | PI3K | Akt
Troxerutin Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |
Chengdu ChenLv Herb Co.,Ltd | +86-13608205856; +undefined13608205856 | maryextract@126.com | China | 127 | 58 |
Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 | info@hyper-chem.com | China | 295 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531153977 | allison@yan-xi.com | China | 5855 | 58 |
Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18147 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 431 | 58 |
Aurora Industry Co., Ltd. | +86-13591747876 +86-13591747876 | alex1_auco@126.com | China | 299 | 58 |
Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 | niki@zlchemi.com | China | 3712 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18949 | 58 |
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View Lastest Price from Troxerutin manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2025-02-14 | Troxerutin
7085-55-4
|
US $10.00 / kg | 1kg | DAB1999,EP9 | 10000 | Changsha Staherb Natural Ingredients Co., Ltd. | |
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2025-02-14 | Troxerutin
7085-55-4
|
US $50.00 / kg | 1kg | 99 | 5000 | Hebei Zhuanglai Chemical Trading Co Ltd | |
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2025-02-12 | Troxerutin
7085-55-4
|
US $0.00-0.00 / Kg/Drum | 1KG | 99%min; EP | 500KG | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Troxerutin
7085-55-4
- US $10.00 / kg
- DAB1999,EP9
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Troxerutin
7085-55-4
- US $50.00 / kg
- 99
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- Troxerutin
7085-55-4
- US $0.00-0.00 / Kg/Drum
- 99%min; EP
- WUHAN FORTUNA CHEMICAL CO., LTD